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Transplantation of biomaterials and/or stem cells into the rat model of spinal cord injury and neurodegenerative diseases
Czech Republic (IFMSA CZ) - Charles University, 2nd Medical Faculty, Prague
Department of Neuroscience, 2nd Medical Faculty, Prague
Assoc. Prof. Lydia Vargova, MD., Ph.D.
Dr. Pavla Jendelova, Ph. D., Sarka Kubinova, Jiri Ruzicka, M. Sc., Dmytri Tukmachev,M.D.
Type of Research Project
- Basic science
What is the background of the project?
The main topics of the project are isolation, labelling and the use of stem cells for the treatment spinal cord injury. Various types of cells (mesenchymal stem cells, neural precursor cell lines derived from fetal spinal cord, or from induced pluripotent cells) are studied, together with anti-inflammatory substances for their potential to promote the regeneration of nervous tissue. Macroporous polymeric hydrogels are used as suitable carriers for cell growth in in vitro cultures as well as for in vivo implantations.
What is the aim of the project?
The aim of the project is to determine the effect of transplantation of biomaterial and/or different types of stem cells into the rat spinal cord injury.
What techniques and methods are used?
Surgical techniques of experimental models of spinal cord injury, cell cultivation, implantation of cells and biomaterials into the spinal cord, behavioral testing for evaluation of the treatment
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Students will learn about different models of acute and chronic spinal cord injury, different types of stem cells and biomaterials, different methods of behavioral testing and immunohistochemical analyses.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
A theoretical introduction to the project and a manuscript with additional infromation will be provided. During their stay, students may attend lectures and seminars for postgraduate students trained in the Department of Neuroscience and in the Institute of Experimental Medicine AS CR.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The students are supposed to have basic neurophysiological and laboratory skills, knowledge of neuroanatomy and neurophysiology in the scope of undergraduated medical students.
Are there any legal limitations in the student’s involvement
If the student does not have a certificate for animal handling, they will not be allowed to work with laboratory animals.
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- PÊGO; A. P.; KUBINOVA S.; CIZKOVA D.; VANICKY I.; MAR M. F.; SOUSA M. M.; SYKOVA E. Regenerative medicine for the treatment of spinal cord injury: more than just promises? Journal of Cellular and Molecular Medicine. 2012; 16(11); 2564-2582. DOI: 10.1111/j.1582-4934.2012.01603.x. ISSN 15821838.
- - KUBINOVA S.; SYKOVA E. Biomaterials combined with cell therapy for treatment of spinal cord injury. Regenerative Medicine. 2012; 7(2); 207-224. DOI: 10.2217/rme.11.121. ISSN 1746-0751.
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