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Electrophysiological and morphological properties of glial cells after brain injury and transplantation
Czech Republic (IFMSA CZ) - Charles University, 2nd Medical Faculty, Prague
Department of Neuroscience, 2nd Medical Faculty, Prague
Assoc. Prof. Lydia Vargova, MD., Ph.D.
English, Czech, Slovak
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The aim of the proposed project is to use electrophysiological and immunocytochemical techniques to study the membrane properties and morphology of oligodendroglia and astroglia in rat brain and spinal cord after transplantation and brain injury.
What is the aim of the project?
The purpose of the study is to obtain new information about the electrophysiological, morphological and immunocytochemical properties of glial cells in transplanted nervous tissue, in implanted hydrogels and about reactive glial cells in injured nervous tissues.
What techniques and methods are used?
Patch-clamp, conphocal microscopy, 3D morphometry, Ca-immaging
What is the role of the student?
- The tasks will be done under supervision
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
What are the tasks expected to be accomplished by the student?
The student will have an opportunity to learn electrophysiological patch-clamp technique and calcium imaging technique, both used to study functional properties of living glial cells. Apart from practical skills, students will acquire theoretical knowledge about glial cell types and their cross-communication with neurons in the brain tissue under physiological and pathophysiological conditions.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
A theoretical introduction to the project and a manuscript with additional infromation will be provided. Weakly internal seminars focused on the topic theory and interpretation of experimental results. Final presentation of the results by SCORE student.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of neurophysiology.
Are there any legal limitations in the student’s involvement
If the student does not have a certificate for animal handling, they will not be allowed to work with laboratory animals.
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Parpura; V.; Heneka; M. T.; Montana; V.; Oliet; S. H. R.; Schousboe; A.; Haydon; P. G.; Stout; R. F.; Spray; D. C.; Reichenbach; A.; Pannicke; T.; Pekny; M.; Pekna; M.; Zorec; R. and Verkhratsky; A. (2012); Glial cells in (patho)physiology. Journal of Neurochemistry; 121: 4–27. doi: 10.1111/j.1471-4159.2012.07664.x
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