Projects
Name
Evaluation of quality of life in patients submitted to Direct Antiviral therapy versus Hepatitis C Virus infection
University
Universita degli Studi di Catania
Domain
Infectious Diseases
Departement
Unit of Infectious Diseases, Hospital Garibaldi Nesima via Palermo 636 I-95100 Catania (Italy)
Head
Prof. Bruno Cacopardo, Dr Francesco Benanti
Tutor
Prof. Bruno Cacopardo, Dr Francesco Benanti
Languages
English; Italian
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No No Yes No No No No
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Currently, therapy of chronic Hepatitis C Virus (HCV) hepatitis and cirrhosis is possible by a feasible and safe treatment that is changing rapidly. Peginterferon and ribavirin are no longer the standard of care therapy and are being replaced by new drugs with greater efficacy and fewer adverse effects. These new direct-acting antivirals (DAAs), incorporated in interferon-based or all-oral regimens, cure more than 90% of infections, even in patients before considered difficult to treat, such as cirrhotic and non-responders. This kind of therapy requires the use of several direct antiviral agents, in detail, using protease inhibitors, NS5a inhibitors, polymerase inhibitors. A great number of antiviral drugs is pangenotypic which means that act on genotype 1 to 4 HCV infection.
What is the aim of the project?
The study aims to evaluate whether eradication of viremia coincides with a melioration of neurocognitive functions and quality of life, since HCV is a multiorgan virus affecting multiple functions apart from hepatic ones.
What techniques and methods are used?
- In the first step, fibrosis staging will be determined in Kilopascal units by clinical exam followed by Fibroscan test. - In the second step, viremia will be evaluated by Real Time Polymerase Chain Reaction. - In the third step a neurocognitive test such as Montreal Cognitive score will be applied for neurocognitive and quality of life evaluation. - In the fourth step, statistical analysis will be performed by two way analysis of variance.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project is clinical
- the student will be allowed to work with patients
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student is supposed to attend regularly the research internship, to be cooperative. It will be important to participate willingly to the activities, maybe giving new point of view to the tutor. The student will be involved in analysis of data and statistical evaluation. Than he will also be helping the tutor in clinical evaluation on the single patients involved in the research program. The student will be trained in performing the whole clinical exam, the evaluation of analysis result, the Fibroscan, the administration of neurocognitive testing. He will also participate to clinical rounds.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Theoretical teaching provided. Teaching will be performed in the form of lectures and seminars mainly on viral hepatitis and AIDS, With some pharmacological extension on the role of antivirals and antibiotic therapy.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Nono
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
Articles
- Association of t(14;18) translocation with HCV infection in gastrointestinal MALT lymphomas Author links open overlay panel:MassimoLibra; AnnunziataGloghini;GraziaMalaponte;PietroGangemi;ValliDe Re;BrunoCacopardo;Demetrios A.Spandidos;FerdinandoNicoletti;FrancaStivala;Anna LindaZignego;AntoninoCarbone