Projects
Name
GEriatricPatients living with HIV/AIDS: a Prospective multidimensional assessment of an ageing cOhort & community
University
Universita degli Studi di Catania
Domain
Infectious Diseases
Departement
Unità operativa di malattie infettive ARNAS Garibaldi Via Palermo, 636, 95122 Catania CT
Head
Prof. Benedetto Maurizio Celesia
Tutor
Prof. Benedetto Maurizio Celesia
Languages
English; Italian
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No No Yes No No No No
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
The greying of people living with HIV is a matter of fact and future projections clearly indicate that HIV disease will intersect geriatric medicine. Even though health generally worsens with age and individual diseases accumulate, the relationship between aging and health is dynamic and periodic improvement and stability in health are common.To better understand aging among people with HIV and factors contributing to the rate of aging, there is value in looking beyond risk for individual age-related diseases Effectively treated HIV infection is associated with excess risk for multiple illnesses, including cardiovascular disease, osteoporosis and chronic obstructive pulmonary disease.These conditions are all strongly age-related, leading to geriatric syndromes. Besides HIV-infected individuals have experienced a dramatic improvement in life expectancy in the modern antiretroviral therapy (ART) era, particularly those who initiated therapy at early disease stages. HIV is still associated with an increased risk of multimorbidity and geriatric syndromes. An HIV specificity in geriatric HIV care does exist.
What is the aim of the project?
Primary Objectives: • To describe health transition in geriatric (>=65 years of age) HIV-positive versus community dwelling HIV-negative individuals. • To describe the incidence of single comorbidities, multi-morbidity, frailty, physical function, disability and changes in quality of life; • To identify specificity of the medical needs of HIV-positive patients; • To characterize poly-pharmacy, the number of drug-drug interactions and potentially inappropriate prescriptions (using Beer and STOPP and START criteria);
What techniques and methods are used?
• In the first step HIV history and antiretroviral prescription (HIV-positive patients only) will be analyzed; • In the second step, patients will be asked to bring in all medications and herbal remedies they are taking at the time of each visit. • In the third step a standard blood test will be performed: a. in HIV-positive patients: screening according to Italian guidelines and local clinical practice. b. in HIV-negative patients: as and if clinically indicated. • In the fourth step anthropometry mesures will be collected, including weight, height and waist circumference, in order to compare results of HIV-positive patients with HIV-negative ones. • In the fifth step clinical evaluation will be performed, including exams like trail making test for cognitive functions and cardio training for physical functions. nutrition and general quality of life will be measured through World health organization (WHO) quality of life scale: https://depts.washington.edu/uwcssc/sites/default/files//hw00/d40/uwcssc/sites/default/files/WHO%20Quality%20of%20Life%20Scale.pdf • In the sixth step Adherence will be measured: Visual Scale, time of antiretrovirals and other medication intake. all examinations performed as part of routine clinical care will be recorded in the GEPPO database.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project is clinical
- the student will be allowed to work with patients
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student is supposed to attend regularly the research internship, to be cooperative. It will be important to participate willingly to the activities, maybe giving new point of view to the tutor. The student will be involved in analysis of data and statistical evaluation. He will also be helping the tutor in clinical evaluation on the single patients involved in the research program. Student could follow the ward and outpatients activity and be able to integrate information coming from the collected data with clinical features of the patients.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
None
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
None
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Pre-Medical students from the American-British system
Articles
- Giallongo C; Parrinello N; Tibullo D; La Cava P; Romano A; Chiarenza A; et al. Myeloid derived suppressor cells (MDSCs) are increased and exert immunosuppressive activity together with polymorphonuclear leukocytes (PMNs) in chronic myeloid leukemia patients. PloS one. 2014;9(7):e101848. PubMed PMID: 25014230. Pubmed Central PMCID: 4094386.