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Anti-malarial Treatment Protocol and how it is used to prevent, control and treat Clinical Cases of Malaria.
Sudan (MedSIN-Sudan ) - University of Gezira, Wad Medani, Gezira
Blue Nile National Institute for Communicable Diseases
Professor Bakri Yousif
Dr. Hassan Hamdi Suliman Dr. Hiba Bakri Professor Samira Hamid Abdelrahman Professor Bakri Yousif
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Antimalarial drugs are use to prevent the onset of disease , to treat clinical cases in individuals and to prevent disease transmission within-population. Some drugs include doxycycline, proguanil and pyrimethamine attack the liver stage of the parasite preventing the release of parasites into the bloodstream. Others such as chloroquine and quinine amongst many others kill the parasite within the red blood cells. Malaria is an endemic disease in Sudan particularly in Gezira State so this research topic is very important based on a problem that all Sudan citizens may suffer from. However, we are observing that current anti-malarial treatments are inappropriate in many of our missions. In other countries where chloroquine is used, we know that this medication is very likely ineffective, but we don’t have adequate data regarding reliable alternative treatment. This training includes lectures and clinical rounds and dealing with patients.
What is the aim of the project?
This project aims to study the anti-malarial drug protocol to prevent and treat clinical cases.
What techniques and methods are used?
A- First step is malaria detection: malaria can be detected by lab testing methods like Microscopy and Polymerase chain reaction. 1_Microscopy: Microscopy is still considered the “gold standard” for malaria diagnosis in endemic countries. This method has a sensitivity of 50–500 parasites/μl , microscopic diagnosis in many areas of sub-Saharan Africa, the WHO recommends RDTs as a good alternative method for malaria diagnosis Lab methods: Thin and thick slides were made in the participants’ homes, where the blood samples were also taken on Whatman paper. Slides of the peripheral blood specimens were made immediately after collection on a clean, grease-free microscope slide and allowed to air dry. The films were stained with 10% Giemsa solution (Appichem, Panreac ITW Companies) for 10 min and examined by microscopists 2_Polymerase chain reaction (PCR) is the most sensitive method available, detecting parasitemia as low as 2–5 parasites/μl. However, it is not appropriate for use in the field, as it is an expensive and complex method. B- Second step is how to treat the clinical cases by following the international Anti-malarial treatment protocol, this will be inside wad medani teaching hospital. C- Third step study of malaria prevention and control.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- If the project is clinical
- the student will take active part in the clinical examination
- If the project is clinical
- the student will be allowed to work with patients
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Microscopic detection of malaria parasites, participation in "Parasitic Control Program", joining small working groups to review some scientific research articles then implementing outputs. Active participation in Wad Medani teaching hospital to take samples from patients then working in the lab to detect the parasites. Participation and following the guidelines and protocol of malaria treatment by attending lectures , small working groups, seeing clinical cases and hospital visits.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
60% lab work and practical (research) 20% Clinical. 20% work groups (extracting outputs from research articles) and implementation of malaria control and prevention.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Medical student. Basic lab-work skills.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Students in biomedical fields
- The East African Network for Monitoring Antimalarial Treatment The efficacy of antimalarial monotherapies; sulphadoxine–pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. Trop Med Int Health. 2003; 8: 860-867
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