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Pre-analytic phase development of breast cancer specimens handling
Thailand (IFMSA-Thailand) - Faculty of Medicine, Khon Kaen University, Khon Kaen
Assoc. Prof. Supinda Koonmee
Assoc. Prof. Supinda Koonmee
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
In developing countries; such as Thailand, many breast cancer patients outcome are not good enough if compare to developed countries. Biomarker; estrogen receptor (ER), progesterone receptor (PR) and HER2 are prognostic and predictive factors of breast cancer treatment. The number of targeted therapy is limited as high number of triple negative test (ER/PR/HER2 are negative result) and currently go through unnecessary chemotherapy, a painful and harmful procedure that destroys every single cell. This is because breast cancer specimens are not well preserved and too long logistic time, before it can be diagnosed at a pathology laboratory.We are interested to developed the solution of breast cancer specimens handling in order to decrease number of triple negative test.
What is the aim of the project?
The aim of the project is to determine ER/PR/HER2 in pre-analytic phase development of breast cancer specimens handling.
What techniques and methods are used?
1. Collecting data of breast cancer specimens in a) pre-analytic phase; cold ischemic time, fixative duration b) analytic phase; tumor size, histologic grade, ER, PR, HER2 and c) post analytic phase; clinical status and treatment.2. Comparison molecular subtype of this project withroutine service.3. Data analysis and quantification will be performed.Data will be analyzed with SPSS statistical software system.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
- Attending gross examination and microscopic examination of breast cancer specimens in pathology laboratory- Study histologic grading of breast cancer - Study breast cancer molecular subtype - Attending immunohistochemistry technique in breast cancer tissue- Study pre-analytic, analytic and post-analytic phase and impact factors for breast cancer treatment - Attending in operation room how to collect breast cancer specimens- Attending Mammo-Patho conference - Collecting data of biomarker profile of breast cancer patients and analyzed with SPSS (statistical software system - Report impact of the implementation Internet of Things (IoT) in breast cancer specimens handling in Srinagarind hospital, Faculty of Medicine, KKU such astriple negative rate (ER-/PR-/Her-)
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Reading of breast cancer treatment and prognosticfactors/ predictive factors. Documents will be sent to the students.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Prefer to learn or train in gross and microscopic examination.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- David G. Hicks; Linda Schiffhauer. Standardized Assessment of the HER2 status in breast cancer by immunohistochemistry. Labmedicine 2011 Aug;12(8): 459-467.
- National Comprehensive Cancer Network (NCCN) Clinical Practice Guideline in Oncology; Version 3.2013. www.nccn.org/professionals/physician_gls/PDF/breast.pdf. Accessed December 20; 2016.
- Soerjomataram I; Louwman MW; Ribot JG; et al. An overview of prognostic factors for long-term survivors of breast cancer. Breast Cancer Res Treat 2008;107:309-330.
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