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Impact of pre-neoplastic lesions and tumors of Gastro-Intestinal tract in African population in Parma area based on pathology records
Universita degli Studi di Parma
Dept. of Surgery and Medicine Via Gramsci 14 Parma 43126, Italy
Prof. Gian Luigi de’ Angelis
Prof. Gian Luigi de’ Angelis
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
In 2016 about 40,92 million of people worldwide have suffered of a cancer and about 12 million of people (30%) have died by a cancer. Among all, gastrointestinal neoplasia (GIN) are the most frequent (26%): 11 million of people have had a GIN and 3 million of patients have died by a GIN. Moreover, GIN have been responsible for 1,107.01 Disability-Adjusted Life Years (DALYs) lost, measured both from years of life lost and years lived with a disability (total burden of disease), where one DALY equals one lost year of healthy life. In the same period in Italy we have had 290,905 of GIN, 49739 deaths and 690.08 DALYs (38,03%) whereas in North-Africa and Sub-Saharan regions 361,954 patients, 187,942 deaths and 1134.564 (79,94%) DALYs. The tumors of the esophagus, stomach and pancreas are more frequent in African patients, while colorectal cancers are more frequent in Italians.
What is the aim of the project?
Aim of the study is to understand how life habits and environment can be crucial in GIN development modifying their epidemiology, clinical features and prognosis.
What techniques and methods are used?
1. We extrapolate and examine 66,718 patients from the database of the Pathology of the Parma Hospital, from 01/01/2007 to 30/12/2017: 24,683 chronic gastritis, 1,080 gastric adenocarcinoma, 36,988 colonic polyps and 3,685 large intestine carcinoma, 55 esophageal epidermoid carcinoma and 227 pancreatic adenocarcinoma. 2. The data obtained will be submitted to non-parametric analysis by a statistician. 3. We use some laboratory techniques such as routine staining, immunohistochemical staining and, where the need arises, molecular biology techniques, as well as PCR (Polymerase Chain Reaction) and FISH (Fluorescence In Situ Hybridization), to study the origins of the pre-neoplastic lesions and tumors.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will take a part of clinical activities and, just in case, will attend the macroscopic examination of surgical specimens. He/she will discuss the pathological features, will collect the clinical and/or any relevant data concerning the study and finally, she/he will critically discuss with the group and with the tutors of the obtained results and of the programmatic research lines. The student will be responsible for the extrapolation of data which, however, will be collected under the supervision of a tutor.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student will be provided with articles, lecture and preliminary readings on the major features of the searched pathologies
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student will have to recognize the main gross features and, as regards the neoplastic lesions, the modifications induced by the tumors, in order to proper process surgical specimens. She/He should be able to observe histological preparations under a light microscope, recognize preneoplastic and neoplastic lesions on Ematoxilin-Eosin slide(s). He/She will have to know the basic principles of immunohistochemistry, when and how to apply it.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Kyoto global consensus report on Helicobacter pylori gastritis
- • Kentaro Sugano1; Jan Tack2; Ernst J Kuipers3; David Y Graham4; Emad M El-Omar5; Soichiro Miura6; • Ken Haruma7; Masahiro Asaka8; Naomi Uemura9; • Peter Malfertheiner10; on behalf of faculty members of Kyoto Global Consensus Conference
- Gut Online First; published on July 23; 2015 as 10.1136/gutjnl-2015-309252
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