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Coroprevention: Personalized Prevention for Coronary Heart Disease
Belgium (BeMSA) - UHasselt, Hasselt
Department of Cardiology
Prof. Dr. Paul Dendale, Dr. Martijn Scherrenberg
Prof. Dr. Paul Dendale, Dr. Martijn Scherrenberg
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
European Coronary Heart Disease (CHD) burden is unsustainable. Better risk stratification tools and personalized care of patients are needed for reducing morbidity and mortality of CHD and the associated economic burden. To this end, we have planned to shape and implement a personalized secondary prevention program for patients with established CHD. This precision strategy will be tested in a prospective trial, the CoroPrevention Trial, a central element of our proposal. We aim to significantly reduce the numbers of coronary events by using outcome risk- and patient characteristics- guided prevention in CHD patients. Firstly, there will be prospectively evaluation of the clinical utility of personalized prevention in CHD, which will be followed with an evaluation of the health economic and social benefits of the prevention in CHD. This will be followed by searching for predictive markers of drug treatment response in CHD. Another crucial subject we will focus on is the improvement of the current European Society of Cardiology (ESC) guidelines based on Randomized Controlled Trial (RCT) validated clinical data. Lastly, we will disseminate the refined prevention program to the attention of practitioners, patients, health care payers and policymakers. This program will establish a new economically sustainable personalized treatment practice applicable throughout Europe particularly to those regions where CHD prevention needs upgrading. The used protocols and technologies will carefully be assessed by the National Institute for Health and Care Excellence (NICE) using their standard evaluation methods that will allow independent expert opinions for different European authorities and decision-makers. These opinion statements will further be supported by full Health Economics analyses of CoroPrevention Trial.
What is the aim of the project?
Improving secondary prevention of acute coronary syndromes.
What techniques and methods are used?
The first step will be a literature search of Digital Health trials in the secondary prevention of ischemic heart disease. The next step is participating in prospective randomized controlled trials conducted in Jessa Hospital testing a mobile application for long term management of ischemic heart diseases. All patients with ischemic heart disease will be included. The exclusion criteria are no possession of a smartphone, contra-indication for exercise and life expectancy of fewer than 6 months. The variables still have to be decided because multiple trials with the same application in different target groups will run at the same time. All these trials will collect different variables. Possible variables are questionnaires, exercise capacity, usage data of the smartphone and general clinical data. The data will be collected in a secured database. The statistical tests will vary between the various target groups. At this moment, the statistical program still has to be decided.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
A literature search of digital health trials in the secondary prevention of Ischemic Heart Disease (IHD). Participation in team meetings about this project. Speaks Dutch: Inclusion of patients, taking questionnaires. Doesn’t speak Dutch: Following the exercise testing and the inclusions of the study together with a researcher. Chance to set-up a trial by preparing a study protocol for a specific target group. Helping writing reports of finished studies. The patient is also expected to do a presentation at the end of the internship about Digital Health and about what they learned during this period. Chance to follow experienced medical doctors in their work
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student will receive additional information in short presentations by the team + preliminary reading. This will be done for the first two days of the internship.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic medical knowledge, basic statistical skills
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Students in biomedical fields
- Kotseva K; De Backer G; De Bacquer D; et al. Eur J Prev Cardiol. 2019;26(8):824–835. doi:10.1177/2047487318825350
- Frederix I; et al. Eur J Prev Cardiol. 2016 May;23(7):674-82
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