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Study of macular edema - complication of diabetic retinopathy
Moldova (ASRM) - State University of Medicine and Pharmacy Nicolae Testemițanu, Chișinău
Ophthalmology; MD 2025 Chisinau – Moldova str. Testemitanu 29
PhD, associate prof. Angela Corduneanu, Cristina Scerbatiuc
Required English, accepted Romanian
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Diabetic macular edema is a thickening of the central retina, or the macula, and is associated with long‐term visual loss in people with diabetic retinopathy. Optical coherence tomography (OCT) is based on optical reflectivity and is able to image retinal thickness and structure producing cross‐sectional and three‐dimensional images of the central retina. It is widely used because it provides objective and quantitative assessment of macular edema. The use of OCT in the diagnosis of diabetic macular edema might provide complex and useful data for the following process of study and treatment of the mentioned disorder.
What is the aim of the project?
To determine the diagnostic accuracy of optical coherence tomography (OCT) for detecting diabetic macular edema, in patients referred to ophthalmologists after diabetic retinopathy (DR) is detected.
What techniques and methods are used?
The first step in the diagnosis of diabetic macular edema (DME) is the contact lens-aided slit-lamp biomicroscopy of the posterior pole. Biomicroscopic examination reveals the presence and location of macular thickening, exudates, and cystoid changes. Fundus fluorescein angiography (FFA) – technique used for examining the circulation of the retina and choroid using a fluorescent dye and a specialized camera. Sodium fluorescein is added into the systemic circulation, the retina is illuminated with blue light at as wavelength of 490 nanometers, and an angiogram is obtained by photographing the fluorescent green light that is emitted by the dye. It may show the areas of retinal capillary leakage. Optical coherence tomography (OCT) – noninvasive imaging technology used to obtain high resolution cross- sectional images of the retina. The layers within the retina can be differentiated and retinal thickness can be measured to aid in the early detection and diagnosis of retinal diseases and conditions. It can show retinal section images. The data obtained from the mentioned techniques is going to be collected and analyzed, in order to obtain a clear perspective whether the OCT can be used for diagnosis of macular edema and how accurate it is.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student is going to: - Perform basic ophthalmological examination of the patients; - Record fundus fluorescein angiography (FFA); - Record optical coherence tomography (OCT); - Collect data obtained from basic examination, OCT and FFA; - Analyze, compare and sum up the results of the examinations; - Form a conclusion and present it through a scientific report.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student is going to have upon arrival theoretical teaching such as reading materials and individual courses assured by the tutor
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
- To know the terms used in ophthalmology; - To be able to perform a basic ophthalmological examination; - To know how what is optical coherence tomography(OCT) and fundus fluorescein angiography; - To be able to analize data and make a conclusion
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Zhang X; Zeng H; Bao S; Wang N; Gillies MC. Diabetic macular edema: new concepts in patho- physiology and treatment. Cell Biosci. 2014;4:27. doi:10.1186/2045-3701-4- 27.
- Browning DJ; McOwen MD; Bowen RM; Jr; O’Marah TL. Comparison of the clinical diagnosis of diabetic macular edema with diagnosis by optical coherence tomography. Ophthalmology. 2004;111(4):712–715.
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