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The connection between hepatic and endocrine conditions and outcomes of cardiac surgeries
Hungary(HuMSIRC)- Semmelweis University,Budapest
Semmelweis University Department of Anesthesia and Intensive Care, Budapest, Hungary, Üllői út 78 .
Andrea Székely MD
Andrea Székely MD
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
The back and forth link between the heart and the liver is well-known for several years. In a pathophysiological aspect the liver damage is caused by stasis, or low cardiac output. We can measure the liver condition with several parameters: transaminase levels, MELD-scores, Doppler-US imaging of hepatic veins. The outcomes we keep our eyes on after cardiac surgery: Acute Kidney Injury, mortality, need for mechanical circulatory support. We use IBM SPSS Statistics 22 for data analysis, which is a software used for interactive, or batched, statistical analysis.
What is the aim of the project?
To find some new, uncommon pathophysiological parameters which can predict worse outcomes among cardiac surgeries.
What techniques and methods are used?
Doppler Ultrasound imaging of the hepatic veins. Data collection from patient databases of the Heart and Vascular Center, Semmelweis University in Budapest, Hungary. We mostly investigate the hepatobiliary markers, hemodynamic parameters, echocardiographic parameters, the need for mechanical cardiac support, demographic parameters, and United Network for Organ Sharing and Model for End-Stage Liver Disease (MELD) scores. The data analysis is being done using the IBM SPSS Statistics 22 software which offers advanced statistical analysis, text analysis, open source extensibility, and integration with big data.
What is the role of the student?
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
1. Assistance at the data collection, which is mostly done on computer. Preoperative data and laboratory markers have to be retrieved from electronic records as well as postoperative data. Help with the calculation of MELD scores. Furthermore, Doppler Ultrasound Imaging is also part of our research, students are expected to collaborate at this part of the study as well. 2. Assistance at data analysis using IBM SPSS Statistics 22 software.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, a short introduction e-learning material on how to use the Doppler-Ultrasound Device.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of anesthesia, intensive care medicine and cardiology. Physical Examination methods. Furthermore, basic knowledge of microsoft word and excel. ☐ Subjects passed: Physiology, Pathology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- E. Holndonner-Kirst; A. Nagy; N.R. Czobor; et al. Higher transaminase levels in the postoperative period after orthotopic heart transplantation are associated with worse survival J Cardiothorac Vasc Anesth; 32 (2018); pp. 1713-1720 https://doi.org/10.1053/j.jvca.2018.01.002
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