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Theoretical and practical education in the Tissue- typing laboratory (in accordance with EFI Standards)
Croatia (CroMSIC) - University of Rijeka, Rijeka
Tissue Typing Laboratory, Clinical Institute for Transfusion Medicine, Clinical Hospital Center Rijeka
prof. prim. dr. sc. Sanja Balen, dr. med.
Nataša Katalinić, MD, PhD
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The project is designed to provide training in the areas of histocompatibility and immunogenetics. Both areas support solid organ transplant programs that exist at the Clinical Hospital Centre Rijeka as well as other programs where diagnosis relies on immunogenetics.
What is the aim of the project?
The aim of the project is to provide training and knowledge in the areas of Histocompatibility and immunogenetics testing, HLA antibodies, and transplantation immunobiology.
What techniques and methods are used?
The training wil be focused on the theoretical and practical aspects of histocompatibility testing and transplant immunology. The training will consist of the following components: 1. Educational - tutorials with the laboratory co-director and supervisors to discuss principles and concepts of laboratory procedures and testing method technologies, new technologies and recent literature - history of clinical histocompatibility - inheritance of HLA antigens and relevance in transplantation - nomenclature of HLA antigens 2. Practical – - the student will be instructed on all techniques used in the Histocompatibility laboratory and on-the-bench training will be provided in each area of the laboratory testing serological procedures: - cell isolation techniques - cryopreservation and thawing of cells - complement-dependent cytotoxicity (typing, screening, crossmatch) - Luminex-based HLA antibody testing (screening) molecular procedures: - Sequence Specific Primer testing - Luminex-based Reverse Sequence Specific Oligonucleotide testing. 3. Interpretation and Application of laboratory procedures– - interpretation of assay results and reporting of results - application of assay results in solid organ transpantation and transfusion medicine - troubleshooting the problems. 4. Quality and Accreditation Standards – - understanding what quality control (QC) is necessary for each assay performed and why it is done - understanding the measures instituted by the laboratory to monitor quality assurance - understanding the laboratory and technologists’ performance expectations as dictated by the European Federation for Immunogenetics (EFI) standards, including external proficiency testing.
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- If the project is clinical
- the student will take active part in the clinical examination
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Students are expected to understand the principles of histocompatibility and immunogenetics and their clinical application in solid organ transplantation and the diagnosis of certain diseases. Student will be further instructed on all techniques used in the laboratory (both serological and molecular procedures). Additionally, they will be thought about and expected to understand and interpret the assay results, as well as understand their application in solid organ transplantation and transfusion medicine. The aim of the practice is for the student to better understand what quality control is necessary for each assay and to recognize laboratory and technologists’ performance expectations.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Apart from the tutorials with laboratory co-director and supervisors no other theoretical teaching will be provided.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Mehra NK; ed. The HLA Complex in Biology and Medicine: A resource Book. New Dehli: Jaypee Brothers Medical Publisher Ltd; 2010.
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