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Molecular and clinicopathological profile of human breast cancer: inflammatory mediators and their correlation with potential worse prognostic factors.
Brazil (IFMSA-Brazil) - Universidade Estadual do Oeste do Paraná - Campus Francisco Beltrão (UNIOESTE FB), Francisco Beltrão
Laboratório de Biologia de Tumores
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Research project involving the study of inflammatory mediators and molecular patterns in cancer immunopathology, focusing on breast cancer. Breast Cancer (BC) is the most common neoplasia among women and has a high mortality rate worldwide. Increasing molecular knowledge of BC has resulted in its stratification into 4 major molecular subtypes according to hormonal receptor expression. Unfortunately, although the data accumulated thus far has improved BC prognosis and treatment, there have been few achievements in its diagnosis. Thus, the project seeks to establish a correlation between the diagnosis, prognostic and the evaluated molecular mediators.
What is the aim of the project?
This project aims to investigate the molecular mechanisms involved in tumor biology, map and identify the participation of inflammatory mediators and cellular signaling as prognostic determinants and clinical outcomes in human breast cancer.
What techniques and methods are used?
The project includes follow up and perform the collection of biological material extracted from a tumor by a surgeon. This will be done at the Francisco Beltrão Cancer Hospital (CEONC) operating room. Then, the biological material will be processed at the Tumor Biology Laboratory. Several techniques will be used, involving for example cytokine analysis with Enzyme Immunosorbent Assay (ELISA), and chemiluminescence to evaluate the antioxidant activity of a tissue by the emission of photons detected by a luminometer (recording a graph for data analysis) and eventually sequencing of Deoxyribonucleic acid (DNA). Finally, the data analysis, such as media and range deviation, is performed using the Microsoft Excel program.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- If the project is clinical
- the student will take active part in the clinical examination
- If the project is clinical
- the student will be allowed to work with patients
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student can develop various skills during the project with the help of the tutor. Major ones include the collection of biological material in the operating room and sample preparation (eg.: separating tumor tissue and hematocrit) and their subsequent analysis. This will develop practices related to the handling of materials and reagents, as well as the organization of the laboratory and the correct use of necessary instrumentation (such as the luminometer, used for chemiluminescence). Data analysis and quantification practices will also be developed.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminary readings will be given by the tutor and discussion of articles and projects in the area alongside other students, with a workload of up to 4 hours per week.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student must have good communication, initiative, and scientific and investigative spirit. Also, it is recommended that they are familiar with molecular biology techniques.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Panis; C.; et al. "Oxidative stress and hematological profiles of advanced breast cancer patients subjected to paclitaxel or doxorubicin chemotherapy." Breast cancer research and treatment 133.1 (2012): 89-97.
- Panis; C.; et al. "Differential oxidative status and immune characterization of the early and advanced stages of human breast cancer." Breast cancer research and treatment 133.3 (2012): 881-888.
- Panis; Carolina; et al. "Critical review of cancer mortality using hospital records and potential years of life lost." Einstein (São Paulo) 16.1 (2018).
- Panis; Carolina; et al. "Putative circulating markers of the early and advanced stages of breast cancer identified by high-resolution label-free proteomics." Cancer letters 330.1 (2013): 57-66.
- Block; Keith I.; et al. "Designing a broad-spectrum integrative approach for cancer prevention and treatment." Seminars in cancer biology. Vol. 35. Academic Press; 2015.
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