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Genetic and immunological mechanisms of chronic obstructive pulmonary disease - COPD
Macedonia (MMSA) - St. Cyril and Methodius, Skopje
University clinic of pulmonlogy and allergology,
Prof. dr. Dejan Dokikj
Angela Debreslioska MD
English, Serbian, Croatian, Bulgarian
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Chronic obstructive pulmonary disease (COPD) is a complex and heterogenious syndrome, which is a leading cause of death arounf the globe.Exacerbations and commorbidities contribute to the severity of the disease. The ethiology of COPD is complex, attributing to both genetic and environmental factors.Many cells and inflammatory mediators take part in the pathophysiology of this disease. There are several clinical phenotypes of COPD and further investigations and analyses are required to prove the correct mechanisms of inflamation, the mediators involved, identificatory biomarkers and possible mechanisms through which innovative tratment may be obtained.
What is the aim of the project?
To determine genetic risk factors in patients with COPD. To identify the mediators asociated with each clinical phenotype of COPD and their possible use as biomarkers.
What techniques and methods are used?
Patients who present with acute exacerbations of COPD are subjects of this project. Serum levels od alpha-1- antitrypsin will be obtained from laboratoty. Genetic mutation of alpha-1-antitrypsin gene will be made. Lung volume test using spiromethry will be done to asses the lung’s capacity and degree of obstruction. A computerised tomography (CT) of the chest will be made to see the ung parenchyma in detail. Serum concentration of C-reactive protein will be determined as well as levels of fibrinogen, leukocytes, neutrophils, eosinophils, interferon-4, interferon -5, interferon -6, interferon -8, interferon -17, interferon gamma and tummor necrosis factor alpha.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Complete a respiratory physical exam for the patients.This will include: inspection, palpation, percussion and auscultation. Analyzing the chest X-ray and CT together with the tutor. Interpreting the lung volume test. Analysing the genetic and immunological data obtaind from the laboratories regarding the cytokine levels. Integration of all the results to see whether a correlation can be made.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Clinical students, able to obtain medical history, physical exam, basic lab interpretation.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Chung; K F. “Cytokines in Chronic Obstructive Pulmonary Disease.” The European Respiratory Journal. Supplement; U.S. National Library of Medicine; Dec. 2001.
- Zou; Yong; et al. “Serum IL-1β and IL-17 Levels in Patients with COPD: Associations with Clinical Parameters.”International Journal of Chronic Obstructive Pulmonary Disease; Dove Medical Press; 24 Apr. 2017
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