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Coinfection and comorbidities in people living with HIV from a specialized service in the interior of Maranhão
Brazil (IFMSA-Brazil) - Universidade Estadual do Maranhão (UEMA), Caxias
Health Science Department in Caxias
Ana Carla Marques da Costa
Ana Carla Marques da Costa
English, Spanish, Portuguese
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Research project is part of a umbrella project, which studied the prevalence of HPV in women living with HIV. The results contributed to a brief overview of the coinfections and comorbidities and to reduce some gaps in the knowledge of the theme when they affect people living with HIV, besides contributing to the improvement of health actions aimed at preventing and treatment of patients with coinfection and comorbidities collaborating to improve the quality of life of this population. Therefore, the project develops an intensive study for a construction of knowledge about medical treatment on people living with HIV.
What is the aim of the project?
To characterize the occurrence of coinfection and comorbidities in people living with HIV, so it Will be possible to Know more about it in medical treatment.
What techniques and methods are used?
This is a quantitative, descriptive, retrospective and transversal cohort study. RESEARCH SITE The research will be conducted at a reference center, The “Serviço de atendimento especializado” (the specialized service)-SAE, located in the municipality of Caxias-MA. In Caxias, the SAE besides attending people from the urban and rural areas of Caxias, provide support to users from other adjacent cities, working as a reference for treatment for HIV-infected patients with viral hepatitis and other STI. POPULATION AND SAMPLE Currently the SAE in Caxias has on average 850 patients living with HIV registered, estimated data according to the number of medical records opened since 2005, year in which the SAE in Caxias was opened and initiated the attendance to the population. Remembering that the headquarters in Caxias is a reference for the other adjacent municipalities. Some criteria will be selected and used for data collection, where the inclusion criteria were part, only the medical records of diagnosed cases seropositive for HIV between the year 2005 to 2018. Exclusion criteria: Seropositive patients by vertical transmission, incomplete medical records, in this case, lacking tests with CD4 and/or viral load. After the sample calculation was made to obtain the confidence level of the research, this value is estimated on average 432 patients. INSTRUMENT AND DATA COLLECTION TECHNIQUE The base instrument used in data collection was adapted from the SINAN notification form (Sistema de Informações de Agravos de Notificação), which was used by the health professionals of the Testing and Counselling Center - CTA. The adapted instrument will be essential, thus allowing to transfer the necessary information contained in the medical records to the instrument of data collection in an organized manner and consistent with the objectives proposed in the research.The data collection period should start in September 2019 and ended in March 2020, in the SAE building, where the service of the users occurs and where the medical record sare stored. The medical records will be selected according to the inclusion and exclusion criteria, followed by the reading of the same, medical diagnoses, medical and nursing evolutions, besides analyzing the examinations attached, the necessary data were transferred to the collection instrument. DATA ANALYSIS After the collection of descriptive statistical data, the data will be digitized by the program Epiinfo version 3.5.3 of 2011. Next, a careful analysis of the data for frequency calculations, means of the main variables for the elaboration and analysis of the results that will be presented through tables and graphs will be performed. The Odds Ratio (OR) test will be used to cross the data and the chi-square test to infer the results, these will be discussed the basis of the theoretical framework and other researches carried out in the area. LEGAL ETHICAL ASPECTS The initial project was submitted to the Research Ethics Committee of the State University of Maranhão – UEMA, at the Center for Higher studies of Caxias – CESC to assess compliance with the ethical and legal principles of theresearch according to resolution No. 466/2012 of Brazil.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
1.Data search in medical records, articles and other refrences about coinfection and comorbidities of HIV 2. Validating medical records’ information with the patient by an detailed abordation with him, questionaries , beyond realizing physical examination and a medição evolution 3. put the data on Epiinfo for analisation 4. participate of analysis and discussion of the collected data with other referentes and authors, and With the profissionais involved on the search 5. Produce articles for publication and presentation on congress.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, there Will be a preliminar teaching with the tutor and other professionals involved (at least four hous of Theoretical teaching).
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a scientific report - The student will prepare an abstract - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Previous contact with researches and with Epiinfo program.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Toyoda; Hidenori; et al. "Effect of GB virus C/hepatitis G virus coinfection on the course of HIV infection in hemophilia patients in Japan" Journal of acquired immune deficiency syndromes and human retrovirology: official publication of the International Retrovirology Association 17.3 (1998): 209-213.
- Altice; Frederick L.; et al. "Treatment of medical; psychiatric; and substance-use comorbidities in people infected with HIV who use drugs" The Lancet 376.9738 (2010): 367-387.
- Goulet; Joseph L.; et al. "Relative prevalence of comorbidities and treatment contraindications in HIV-mono- infected and HIV/HCV-co-infected veterans" Aids 19 (2005): S99-S105.
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