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Laboratory diagnostics of autoimmune diseases
Macedonia (MMSA) - St. Cyril and Methodius, Skopje
Institute for Immunobiology and Human Genetics.
Prof. dr. Dejan Trajkov
Aleksandar Petlichkovski MD PhD
English, Serbian, Croatian, Bulgarian
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Autoimmune disorders are known not so much a while ago. Also the knowledge concerning autoimmune disorders is growing thanks to the advancements in immunological, genetic and molecular techniques. However it is interesting that the frequency of autoimmune disorders being diagnosed is rising. This information motivates and pushes scientists and researchers to develop novel techniques for determination and quantification of autoantibodies used in the diagnosis of these disorders. In addition to diagnosing such a disease, it is of great importance to use developed measures to use for patients’ follow up and also get insight into the success of the treatment.
What is the aim of the project?
To explain the rationale for laboratory autoimmune diagnostics and basic laboratory principles behind the tests used for diagnosing these autoimmune diseases.
What techniques and methods are used?
The methods that will be used in this project will go as follows: - The patient will be interviewed to see what will be investigated upon - The sample taken from the patient will be prepared to be used in the machines for evaluation. - Laboratory working on the sample will be performed, and -The results gathered will be analyised The techniques that will be used in this project are: - Automated and manual Enzyme Linked Immuno Sorbent Assay, - immunofluorescence antibodies and - flow cytometry.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
What are the tasks expected to be accomplished by the student?
The student is expected to learn the autoimmune diseases that will be tackled here (because it is a dynamic process we cannot tell which autoimune diseases will be covered, as that depends on the patients that will come that month). The student is expected to learn the basic laboratory priniciples of working with patient materials.The student is expected to learn the fundementals of ELISA, immunofluorescence and flow cytometry.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The tutor will provide teaching and explanation during the exchange at the beggining for all that will be done. He will also be available for any questions and concerns along the way.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge of basic physiological and genetic mechanism of immune reactions.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Tozzoli; Renato. “Recent Advances in Diagnostic Technologies and Their Impact in Autoimmune Diseases.” Autoimmunity Reviews; vol. 6; no. 6; 1 Jan. 2007; pp. 334–340.; doi:10.1016/j.autrev.2007.01.005.
- Villalta; Danilo; et al. “The Laboratory Approach to the Diagnosis of Autoimmune Diseases: Is It Time to Change?” Autoimmunity Reviews; vol. 6; no. 6; 1 Oct. 2006; pp. 359– 365.; doi:10.1016/j.autrev.2007.01.009.
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