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Experimental research of neurobiological mechanisms of drug addiction.
Czech Republic (IFMSA CZ) - Charles University, 3rd Medical Faculty, Prague
Department of Pharmacology, Third Faculty of Medicine, Charles University, Prague 10, Czech Republic
PharmDr. Magdalena. Sustkova, PhD.
PharmDr. Magdalena. Sustkova, PhD.
Type of Research Project
- Basic science
What is the background of the project?
Opioids, methamphetamine or cannabis abuse impose a significant burden on individuals and society worldwide, and effective therapy of these drug addictions would provide distinguished social benefits. Addictological research seeks for new potentially effective mechanisms and treatment approaches for drug addiction pharmacotherapy. For example, ghrelin significantly participates in reinforcing neurobiological mechanisms of several drugs of abuse, thus, ghrelin antagonism is proposed as a promising addiction treatment. Our laboratory has been dealing with ghrelin and addiction problematic for several last years; still some important knowledge has remained for testing. Also, some other mechanisms could be considered for our experimental research on drug addiction.
What is the aim of the project?
Experimental research of neurobiological mechanisms of opioids or methaphetamine or cannabis addiction/dependence using appropriate animal models (in rats or mice). Recently in our laboratory, the ghrelin antagonism has been tested as potential new pharmacological approach for treatment of drug addiction. Other new potentially effective mechanisms suitable for addiction treatment will be tested too.
What techniques and methods are used?
Used experimental methods and models: behavioural methods (explorative activity in the open field/activity cage , elevated plus maze, rotary rod, observing of specific behavioural changes/postures etc.), intravenous self-administration in rats, drug-conditioned place prefernce etc., neuro-behavioural methods (central nervous systém microdialysis in vivo in rats combined with observing of concurrent behavioural changes).
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will get familiarized with the theoretical base/appropriate literature concerning the studied problematic. The student will get acquainted with the appropriate research method(s) and its/their purposes, principles and rules, the experimental procedure(s), sampling of data and evaluation/assessment of the gained data and mode of presentation of the results. The student will undergo elementary training of work involving the laboratory animals. In suitable cases, the student might help during the experiments – always under supervision. The student also will prepare (on his own) a short lecture summarizing the situation of drug abuse and drug addiction in his own country (most frequent drugs of abuse, the treatment and preventive approaches etc.)
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student might attend some appropriate chosen lectures or practicums/seminaries (optional/facultative activity of the student).
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Required: good fundamental knowledge of pharmacology (general as well as special pharmacology), biochemistry, anatomy (in particular the central nervous system, brain), etc. The student must not be allergic on animals (rodents) or must not be scared of animals (rodents). The student must not have personal history of drug addiction/dependency Subjects passed: pharmacology, biochemistry, anatomy
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- SUSTKOVA-FISEROVA; Magdalena; PUSHKINA; Nina; HAVLICKOVA; Tereza; LAPKA; Marek; SYSLOVA; K.; POHORALA; V.; CHARALAMBOUS; Chrysostomos: Ghrelin receptor antagonism of fentanyl-induced conditioned place preference; intravenous self-administration and dopamine release in the nucleus accumbens in rats. Addiction Biology; 2019; in press; Article e12845. DOI: 10.1111/adb.12845.
- HAVLICKOVA; Tereza; CHARALAMBOUS; Chrysostomos; LAPKA; Marek; PUSHKINA; Nina; JERABEK; Pavel; SUSTKOVA-FISEROVA; Magdalena: Ghrelin Receptor Antagonism of Methamphetamine-Induced Conditioned Place Preference and Intravenous Self-Administration in Rats. International Journal of Molecular Sciences; 2018; 19(10): Article 2925. DOI: 10.3390/ijms19102925. WoS ID: 000448951000080 Scopus ID: 2-s2.0-85056631042 PubMed ID: 30261633
- JERABEK; Pavel; HAVLICKOVA; Tereza; PUSHKINA; Nina; CHARALAMBOUS; Chrysostomos; LAPKA; Marek; KACER; Petr; SUSTKOVA-FISEROVA; Magdalena: Ghrelin receptor antagonism of morphine-induced conditioned place preference and behavioral and accumbens dopaminergic sensitization in rats. Neurochemistry International; 2017; 110(November): 101-113. DOI: 10.1016/j.neuint.2017.09.013. WoS ID: 000414891600011 Scopus ID: 2-s2.0-85030564827 PubMed ID: 28958601
- SUSTKOVA-FISEROVA; Magdalena ; CHARALAMBOUS; Chrysostomos; HAVLÍČKOVÁ; Tereza; LAPKA; Marek; JEŘÁBEK; Pavel; PUSHKINA; Nina; SYSLOVÁ; Kamila: Alterations in Rat Accumbens Endocannabinoid and GABA Content during Fentanyl Treatment: The Role of Ghrelin. International Journal of Molecular Sciences; 2017; 18(11): Article 2486. DOI: 10.3390/ijms18112486. WoS ID: 000416811300256 Scopus ID: 2-s2.0-85034987422 PubMed ID: 29165386
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