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The interplay of perfusion and plasticity after Stroke
Switzerland (Swimsa) - University of Zurich, Zurich
Institute of Neurology
Susanne Wegener, Will Middleham, M. El Amki
Type of Research Project
- Basic science
What is the background of the project?
Ischemic stroke is a devastating disease and thrombolytic treatments only improve patient outcome if started within the first hours of symptom onset. Time to recanalization crucially influences the chance for recovery (1). However, recent clinical evidence suggests that, even with successful recanalization of the vessel and without complications such as intracerebral hemorrhage (ICH), outcome can be unfavourable. This inefficiency of recanalization, is mainly due to microcirculatory failure and the so-called “no- reflow” phenomenon. Therefore, thrombolytic strategies do not always lead to a successful reperfusion. To describe vascular outcome, reperfusion (restoration of microcirculatory blood flow) must be differentiated from recanalization (removal of the causative clot from a larger artery). After recanalization in stroke patients, a primary clot can break into fragments that migrate and occlude distal arterial branches and sometimes arterioles. Microthrombi have been found in brain microvessels of stroke patients who died within a month but also in patients with successful recanalization. Adequate microcirculation is crucial for neurons to function and survive. The relationship between blood flow and neuroplasticity underscores a complexity of mechanisms through which neurorehabilitation may promote brain circuitry activation. Therefore, understanding and improving the microcirculatory reperfusion may increase the success of thrombolytic treatments and, most of all: patients ‘recovery.
What is the aim of the project?
Aim: to study the occurrence, severity and timing of the no-reflow phenomenon after successful recanalization and its consequences on stroke outcome
What techniques and methods are used?
Thrombin model in rat/ MRI/ Laser Speckle imaging, behavioral testing
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
the student will have a concrete project where they will work on collecting data, analyzing data and reporting results on a specific research question. This project includes a high variety of interesting fields and working areas, such as working with animals, MRIs, Laser Speckle imaging and behavioral testing. The tutors do not expect any specific tasks but the student is welcomed in every field and topic of his interest. There will be tasks with rat included as a lot of basic research is done with rat-models and strokes.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Lab seminars and Journal club
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Interst to see in this specific field of neurology research Please respect the lab rules and follow your tutors advice.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
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