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Mechanisms mediating the eating inhibitory effect of amylin
Switzerland (Swimsa) - University of Zurich, Zurich
Institute of Veterinary Physiology
Christina Neuner Boyle, Thomas Lutz, Christelle Le Foll
Type of Research Project
- Basic science
What is the background of the project?
Gastrointestinal hormones are important controls of eating. One of these hormones, the pancreatic beta-cell hormone amylin, controls meal size. Under chronic conditions, administration of amylin or amylin analogues reduces body weight. Amylin acts in different parts of the brain, mainly in the caudal hindbrain (area postrema) and hypothalamus. The amylin receptor is a complex molecule consisting of various components such as the calcitonin receptor and receptor activity modifying proteins.
What is the aim of the project?
This project will investigate the mechanisms that underlie the effect of the pancreatic hormone amylin on energy homeostasis. Experiments will mainly involve immunohistological analysis of brain areas that are reactive to amylin to decipher the neurotransmitters mediating amylin’s effect.
What techniques and methods are used?
- In vivo experiments (feeding tests; energy expenditure) - Collection of brain for immunohistochemical processing - Manipulation of amylin receptor components
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
No, the student will have a concrete project where they will work on collecting data, analyzing data and reporting results on a specific research question.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Journal club presentations Student and task specific teaching
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Good knowledge of English Motivation Interest in biomedical and basis research
Are there any legal limitations in the student’s involvement
Unless training has already been formally achieved, work with animals can only be done under supervision
Type of students accepted
This project accepts: - Medical students - Students in biomedical fields
- https://www.ncbi.nlm.nih.gov/pubmed/?term=lutz+ta +amylin
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