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Use of photoacoustic imaging in preclinical studies
Universita degli studi di Firenze
Experimental and Clinical Medicine Department (General Pathology Section)
Type of Research Project
- Basic science
What is the background of the project?
The present internship will take place in L.I.Ge.M.A. (genetic engineering laboratory for the production of animal models). In the labs oocytes and blastocysts are harvested and re-implanted in order to produce genetically modified mice models. The animal models include also immunodeficient mice, in which neoplastic cells or small pieces of primary tumors may be implanted subcutaneously, intravenously or orthotopically. In these animal models, we evaluate the ability of human primary tumor to grow and to give metastatic disease. They are also used to treat the efficacy of new drugs on inhibition of primary tumor development and metastases.
What is the aim of the project?
The aim is to evaluate the therapeutic effects of combined treatments of antineoplastic drugs and the ability of human primary tumor to grow and to give metastatic disease.
What techniques and methods are used?
The above mentioned animal models will be analized applying with high frequency ultrasound imaging, photoacustic imaging (PAI). The tool used is VEVOLAZR-X (visualsonics fujifilm). This instrument is used for preclinical applications capable of acquiring anatomical, functional, molecular data in vivo. It combines high frequency ultrasound with photoacoustic imaging to obtain high resolution images. It can be a broad spectrum, from the study of tumor masses, to the characterization of nanoparticles, to microvascularization studies and the presence of hypoxic regions in a tumor growth region.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will practice with the use of photoacoustic imaging and with reading images resulting from ultrasound. He / She will practice with manipulation and use of mice for the purpuose of pre-clinical research. The student will be involved in data analysis using the VEVOLAB software, in order to evaluate the physiological and clinical parameters that emerged from the use of ultrasound and photoacoustic imaging.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
It is required a general knowledge of the basic techniques applied for laboratory research. The rest of the teaching will be provided by the tutor during the course of the internship.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Good level of English, to be able to read scientific papers. Laboratory expertise will be acquired on site.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- - Zhang Y; Hong H; Cai W. Photoacoustic Imaging. NIH Public Access; 2011.
- - Wang S; Lin J; Wang T; Chen X; Huang P. Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications. Theranostics 2016; Vol.6; Issue 13.
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