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IR spectroscopy in determination biochemical changes in tumor tissue
Serbia (IFMSA-Serbia) - University of Belgrade, Belgrade
Department of Pathological Physiology, Faculty of Medicine, University of Belgrade, Serbia
prof.MD Jelena Nešović Ostojić
Prof. MD Silvio De Luka
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The vibrational spectroscopy methods detect all chemical bonds in an examined specimen that are inside the studied spectral range. Due to its sensitivity to any changes in biomolecular compositions, the method has proven itself as excellent for biomedical analyses. Although not strictly microscopy in the conventional sense, it allows the construction of images of tissue or cell architecture by the passing of spectral data through a variety of computational algorithms. Atypical experiment can be completed and analyzed within hours. This makes infrared spectroscopy a valuable tool for the investigation of protein structure of the molecular mechanism of protein reactions and of protein folding, unfolding and misfolding. IR spectroscopy could be seen as crucial in determination of disordered biochemical bonds, which could be used to clarify the etiology of various malignant tumors.
What is the aim of the project?
Search for specific biochemical changes in tumor tissue.
What techniques and methods are used?
Infrared spectroscopy involves the interaction of infrared radiation with matter. It covers a range of techniques, mostly based on absorption spectroscopy. As with all spectroscopic techniques, it can be used to identify and study chemical substances. Samples may be solid, liquid, or gas.
What is the role of the student?
- The student will mainly observe
What are the tasks expected to be accomplished by the student?
To become familiar with this specific method.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Using Fourier transform IR spectroscopy to analyze biological materials Nature Protocols 9(8):1771-1791 · August 2014
- Infrared spectroscopy of proteins. Biochim Biophys Acta. 2007 Sep;1767(9):1073-10
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