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Drug experiments on cardiac hemodynamics, central nervous system activity and drug metabolites
Turkey (TurkMSIC) - Uludag University, Bursa
Bursa Uludag University, Faculty of Medicine, Department of Medical Pharmacology, Izmir Road st. 16059, Gorukle, Nilufer, Bursa
Prof. Dr. Sinan CAVUN
Prof. Dr. Sinan CAVUN
Type of Research Project
- Basic science
What is the background of the project?
Drugs are commonly used medical materials in medicine. When a person takes a drug, the drug varies to its metabolites in body. This metabolites are generally harmless, but some metabolites will be dangerous for organ systems. Pharmacology investigates these systemic effects, drug interactions with each other and tries to find the least harmful substances to human body. Also pharmacology departments conducts consultations with other clinical departments on therapeutic drug monitoring, dose recommendations in clinical practice, unexpected side and toxic effects of drugs. Bursa Uludag University Pharmacology Department has been established at 1974 and works about over 40 years with 7 professors, 1 PhD student, 4 Master degree students and 1 chemist. The student enrolled in this internship will be able to observe the ongoing experiments in the time they are doing the exchange. Currently our department is working on the development of novel pharmaceuticals in the following clinical aspects; - Hemodynamic modifiers and inotropes - Central nervous system activity altering drugs We are also examining the end metabolites of neuroleptics and running some projects looking into alternative chemicals to current guidelines.
What is the aim of the project?
Our department is currently divided in working on cardiac hemodynamic modifier drugs and neuroleptics. The student will be able to observe the Daily routines and study desings of several such projects, as well as having the opportunity to meet with researchers.
What techniques and methods are used?
HPLC(High Performance Liquid Chromatography): Chromatography is a laboratory technique for the separation of a mixture. The mixture is dissolved in a fluid called the mobile phase, which carries it through a structure holding another material called the stationary phase. The various constituents of the mixture travel at different speeds, causing them to separate. HPLC is a form of column Chromatography with a high analytical resolution. Pumps a sample mixture or analyte in a solvent at high pressure through a column with chromatographic packing material. Endogen molecules and drugs are measured from biological samples with these technique. The enzyme-linked immunosorbent assay (ELISA): It is a commonly used analytical biochemistry assay. The assay uses a solid-phase enzyme immunoassay (EIA) to detect the presence of a ligand (commonly a protein) in a liquid sample using antibodies directed against the protein to be measured. Cardiovascular Hemodynamics: Measurement tests about chronic and acut cardiovascular hemodynamy, with electrocardiographic monitoring, arterial catheter, echocardiography. Cerebral Microdialysis: This is a variation of dialysis. Dialysis works on the principles of the diffusion of solutes and ultrafiltration of fluid across a semi-permeable membrane. Diffusion is a property of substances in water; substances in water tend to move from an area of high concentration to an area of low concentration. The technique of microdialysis enables the measuring and monitoring of neurotransmitters and other molecules in brain's interstitial tissue fluid after taking a drug. Experimental psychopharmacology: Researching the effects of drugs that effects central nervous system on different behavior models.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
-Observing to a researcher for learning principles of working in laboratory (Hygen rules, becoming sterile etc.) and successfully applying during the exchange. -Learning to working principles of HPLC, ELISA, behavioral experiments techniques -Learning to basic removal mechanisms of drug metabolites from human body -Learning to a new drug development stages -Learning to treatments applied in drug poisoning -Learning to drug-receptor interactions.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1 hour weekly routine seminars about pharmacology (egg. techniques, cases etc.) by different academicians of the department, depending on availabilities of respective researchers.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
This internship requires that students are able to work with animals and have a certificate of animal experimentation training from their respective countries.
Are there any legal limitations in the student’s involvement
The project contains experimental animal studies. If the student wants to join these studies actively, the student needs to have a Certification of Experimental Animal Usage.
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Goodman And Gilman's The Pharmacological Basis Of Therapeutics; 13th Edition; Laurence Brunton; Bjorn Knollmann; Randa Hilal-Dandan; 2017 ISBN: 9781259584732
- Basic and Clinical Pharmacology 14th Edition; Bertram G. Katzung; 2017; ISBN: 9781259641152
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