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Strategies for the development of nanoparticles in the control of multi-resistant bacteria to antibacterials
Universidade Estadual de Londrina (UEL)
Departament of Microbiology
Gerson Nakazato and Renata Kobayashi
Englush, Portuguese, Spanish
Type of Research Project
- Basic science
What is the background of the project?
In the last years, the concern with multidrug resistant bacteria to conventional antimicrobials has increased significantly. Several natural and synthetic compounds have been evaluated for antimicrobial activity. Nanoparticles of different origins have also been employed for the same purpose. The research group, under supervised coordination, deposited 3 patents, and has published several papers in indexed journals on compositions containing nanoparticles conjugated with other antimicrobials.
What is the aim of the project?
The objective of this project is to evaluate the antibacterial activity of different nanoparticles using strategies of action, controlled release and synergism with other compounds (natural and synthetic).
What techniques and methods are used?
The polymeric and metallic nanoparticles will be synthesized in the laboratory of Basic and Applied bacteriology/Department of Microbiology/ Biological Science Center (CCB)/ Stadial University of Londrina (UEL). The antibacterial effect of the compounds will be evaluated by the techniques of agar-diffusion, microdilution in broth and time-death curve. Alternative models using cell culture and moth larvae will be used for cytotoxicity assays of compounds. Preliminary results showed that some combinations of some nanoparticles with other compounds were efficient against some bacterial strains, including multi-resistant. The project is related to the Biotec 28/2013 project Mcti/CNPQ/CT-"biological Systems Engineering", and UNIVERSAL Mcti/cnpq N º 14/2013. The development of new antibacterial compositions and the incorporation of these into products is an interesting alternative to infection control. Our laboratory has produced biogenic silver nanoparticles, and the financing of this project will be important for the implementation of the synthesis of other types of nanoparticles.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will receive instructions and orientations on the everyday activities of the laboratory and the techniques that are used in the project. It is expected that the student understands strategies for the development of nanoparticles in the control of multi-resistant bacteria during the exchange. The incoming should contribute in the planning of activities, assisting in the experiments of microbiology and development of technological products. In addition, the student should analyze the results, participate in the publication of papers, seminars and meetings of related matters.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes. Seminars (quinzenal) made by the students and readings proposed by the tutor during the internship
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Determination and interest in learning. Subjects passed: Microbiology and general chemistry. Previous experience with: Practice in a laboratory
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Nakazato; G. ; Kobayashi; R.K.T. ; OGATTA; S. F. Y. ; PANAGIO; L. A. ; LONNI; A. A. G. S. ; ALMEIDA; R. S. C. . Grupo usa nanotecnologia para desenvolver novos antimicrobianos. Notícia UEL; Londrina-PR; p. 5 - 5; 23 set. 2015.
- Macedo Ribeiro; Jhonatan (PIBIC-CNPq-AF); Kenji Nishio; Erick; Nakazato;Gerson – UEL AVALIAÇÃO DA ATIVIDADE ANTIBACTERIANA DE NANOPARTÍCULAS DE ÓXIDO DE FERRO EM BACTÉRIAS MULTIRRESISTENTES PERUGINI; V. H. ; JOSE; J. D. ; LUCIO; D. S. ; FONTANA; L.M.S. ; BELEI; R. A. ; CAPOBIANGO; J. D. ; RIBEIRO; M. A. G. ; CARRARA-MARRONI; F. E. ; VESPERO; E. C. ; STIPP-ABE; A. T. ; PERUGINI; M. R. E. . Impacto de um bundle nas taxas de pneumonia associada à ventilação mecânica (PAV) em uma unidade de terapia intensiva pediátrica em Londrina-PR. SEMINA. CIÊNCIAS BIOLÓGICAS E DA SAÚDE (ONLINE) ; v. 36; p. 259-266; 2015.
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