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Prognostic impact of immune checkpoint status in patients with malignant pleural mesothelioma and possibility of therapeutic strategy with immunotherapy
Turkey (TurkMSIC) -Ankara University, Ankara
Ankara University Faculty of Medicine, Department of Thoracic Surgery, Cebeci Mh. Ibni Sina Hospital 06230 Altindag Ankara
Prof. Ayten Kayi Cangir, Md.
Bulent Yenigun, Md.
Type of Research Project
- Global Action Project (GAP)
What is the background of the project?
Malignant pleural mesothelioma (MPM) is the most common primary malignancy of the pleura. Its frequency is high in Turkey, particularly in Cappadocia, due to the asbestos and erionite exposure. It effects individuals at a younger age in Turkey. Currently, there is no effective treatment for MPM and the majority of the patients die within the first year of diagnosis. In this study, we aim to investigate the CTLA-4, PD-1, and PDL-1 immune checkpoints in MPM patients by immunohistochemistry; all of which are important markers that help determine the course and treatment susceptibility of the tumor. We will examine paraffin fixed preparations of 50 patients from our hospital between 1955 and 2016. The results of our study may help guide future patient and treatment selections for cases of MPM.
What is the aim of the project?
The results of our study may help guide future patient and treatment selections for cases of MPM.
What techniques and methods are used?
- Preparation of slides using immunohistochemistry and antibody staining - Enzyme Linked ImmunoSorbent Assay (ELISA) usage for detection of oncogene expressions in surgery specimens - Surgical approaches to the treatment of mesothelioma
What is the role of the student?
- If the project is clinical
- the student will take active part in the clinical examination
- If the project is clinical
- the student will be allowed to work with patients
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The following work will be expected from the student during the time of their exchange: - Scrubbing in and observing the surgeries of mesothelioma patients and having discussions about the procedure and outcomes afterwards. - Observing the collection of pathology specimens from mesothelioma patients in surgeries. - Helping prepare said specimens in the medical pathology laboratory with immunohistochemical processing - Examining the prepared slides to determine the cytological characteristics of mesothelioma - Observing the usage of ELISA for detection of oncogene expressions in surgery specimens The following outcomes will be expected once the exchange is complete: - Prepare a scientific report to be presented to the head of department and the tutor in the Dpt. Of thoracic surgery. The report will focus on the epidemiology, diagnosis and surgical treatment procedures learnt during the exchange. - Prepare a report to be presented to the Dpt. Of Medical pathology. The report will focus on the cytological characteristics of mesothelioma and the pathology lab techniques learnt during the exchange.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The following courses and teachings will be provided: Bulent Yenigun, Md.; Dpt. Of Thoracic Surgery - Scrubbing and operating room hygiene protocols - Pre operational procedures for patients - Surgical approaches to the treatment of mesothelioma Prof. Ayten Kayi Cangir, Md.; Dpt. Of Thoracic Surgery - Pathophysiology and epidemiology of mesothelioma - Diagnosis and surgical treatment of mesothelioma Prof. Isinsu Kuzu, Md. Dpt. Of Medical Pathology - Preparation of slides using immunohistochemistry and antibody staining - Enzyme Linked ImmunoSorbent Assay (ELISA) usage for detection of oncogene expressions in surgery specimens Lectures will normally be provided daily but depend on the availability of the tutors.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
There are no special required skills or legal limitations.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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- - Chirurg. 2016 May;87(5):455-66. doi: 10.1007/s00104-016-0186-1.[Surgical therapy of malignant pleural mesothelioma]. Schirren M1; Sponholz S1; Oguzhan S1; Fisseler-Eckhoff A2; Fischer A3; Schirren J4.
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- Bruce W.S. Robinson; M.D. and Richard A. Lake; Ph.D.2005. ‘’Advances in Malignant Mesothelioma.’’ N Engl J Med.; 353;1591-1603.DOI: 10.1056/NEJMra050152
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