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Tissue engineering and regenerative medicine: from the bench to patient’s bed.
Università degli studi di Novara
Biotechnologies and Informatics
Health Sciences Department
English, French, Spanish, Italian
Type of Research Project
- Basic science
What is the background of the project?
Biomaterials and tissue engineering are growing research fields, which require a multidisciplinary approach, involving biologists, chemistrians, engineers, medics, etc. Innovative biomaterials should show excellent biological and mechanical properties, in order to actively be part of the regenerative process. Because of their exceptional biocompatibility, biological materials are particularly intriguing and more and more used in the biomedical field. For these reasons, the research of innovative biological materials, able to improve the quality of the regenerative process is quickly increasing. The project will focus on the characterization of innovative biomaterials for biomedical applications.
What is the aim of the project?
The aim is to learn the basics of the research related to biomaterials and regenerative medicine.
What techniques and methods are used?
Cellular biology techniques (cell cultures, cell viability assay, immunofluorescence techniques for morphological and functional cell characterization, proteins’ expression for cell differentiation evaluation); materials chemical-physical characterization (morphological and mechanical tests). Team work and critical discussions on obtained results will be also improved.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The students will be required to attend the laboratory daily. They will be required to be autonomous in solutions preparation, maintaining cells culture. All the techniques will be followed by a tutor. As a team work, they will need to be able to be collaborative with the group, learning but also developing a critical approach to research. They will be responsible for the practical activities personally performed. The results obtained will be discussed in team.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Any particular skill is required, but basic knowledge on cellular biology are suggested
Are there any legal limitations in the student’s involvement
Please do not share the results of the research
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- 1. Overview of natural hydrogels for regenerative medicine applications. Catoira MC; Fusaro L; Di Francesco D; Ramella M; Boccafoschi F. J Mater Sci Mater Med. 2019 Oct 10;30(10):115. doi: 10.1007/s10856-019-6318-7.
- 2. Collagen-Based Tissue Engineering Strategies for Vascular Medicine. Copes F; Pien N; Van Vlierberghe S; Boccafoschi F; Mantovani D. Front Bioeng Biotechnol. 2019 Jul 12;7:166. doi: 10.3389/fbioe.2019.00166. eCollection 2019. Review.
- 3. Effect of Cyclic Stretch on Vascular Endothelial Cells and Abdominal Aortic Aneurysm (AAA): Role in the Inflammatory Response. Ramella M; Bertozzi G; Fusaro L; Talmon M; Manfredi M; Catoria MC; Casella F; Porta CM; Boldorini R; Fresu LG; Marengo E; Boccafoschi F. Int J Mol Sci. 2019 Jan 12;20(2). pii: E287. doi: 10.3390/ijms20020287.
- 4. Relevance of inflammation and matrix remodeling in abdominal aortic aneurysm (AAA) and popliteal artery aneurysm (PAA) progression. Ramella M; Bernardi P; Fusaro L; Manfredi M; Casella F; Porta CM; Nicolai L; Galeazzi E; Boldorini R; Settembrini AM; Settembrini P; Marengo E; Cannas M; Boccafoschi F. Am J Transl Res. 2018 Oct 15;10(10):3265-3275. eCollection 2018.
- 5. Decellularized biological matrices: an interesting approach for cardiovascular tissue repair and regeneration. Boccafoschi F; Botta M; Fusaro L; Copes F; Ramella M; Cannas M. J Tissue Eng Regen Med. 2017 May;11(5):1648-1657. doi: 10.1002/term.2103. Epub 2015 Oct 29. Review.
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