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In vivo and ex vivo validation of MR (magnetic resonance) tractography of brain white matter tracts
France (ANEMF) - University of Tours, Tours
iBrain, INSERM U1253 2 boulevard Tonnellé, 37 000 Tours, France
Christophe Destrieux and Igor Maldonado
Type of Research Project
- Basic science
What is the background of the project?
White matter tract connect cortical areas to other parts of the cortex, to basal ganglia and to the brain stem and spinal cord. These tracts form the internal part of the brain and transmit the nervous impulses. Changes in brain white matter may serve as biomarkers for numerous neurological diseases. Diffusion Weighted Imaging (DWI) is a non-invasive MRI (Magnetic Resonance Imaging) technique providing information on white matter tracts (tractography) by studying water diffusion. Since it is based on complex mathematical models that only indirectly evaluates the underlying anatomy, tractography need to be validated before being used for research and clinical purposes. Several validation techniques were previously proposed, none of them being fully conclusive in humans.
What is the aim of the project?
To qualitatively and quantitatively validate in and ex vivo MRI tractography of brain white matter tracts by comparison to Klingler’s dissection, considered as a ground truth
What techniques and methods are used?
- Diffusion Imaging with Magnetic Resonance (MR) - MR tractography: in-vivo and ex-vivo - Preparation of human anatomical (cerebral) specimens - Fiber dissection of the cerebral white matter (Klingler’s technique)
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Participation in: • Fiber dissection of the cerebral white matter (Klingler’s technique) and photographic documentation (both 2D and stereoscopic); • Post-treatement of Diffusion Imaging Magnetic Resonance data; • Reception, conservation, and preparation of human anatomical (cerebral) specimens
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Reading of scientific papers in the field; traning by one of the members of the laboratory; journal club
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Scientific writing, basic neuroanatomy knowledge
Are there any legal limitations in the student’s involvement
For security reasons, pregnant women can not participate to part of the experiments in our laboratory (use of chemicals).
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Students in biomedical fields - Dental medicine students (IADS members)
- • Maldonado IL; de Champfleur NM; Velut S; et al. Evidence of a middle longitudinal fasciculus in the human brain from fiber dissection. J Anat 2013; 223: 38-45. 2013/04/30. DOI: 10.1111/joa.12055.
- • Maldonado IL; Mandonnet E and Duffau H. Dorsal fronto-parietal connections of the human brain: a fiber dissection study of their composition and anatomical relationships. The Anatomical Record 2012; 295: 187–195.
- • Zemmoura I; Serres B; Andersson F; et al. FIBRASCAN: a novel method for 3D white matter tract reconstruction in MR space from cadaveric dissection. Neuroimage 2014; 103: 106-118. 2014/09/23. DOI: 10.1016/j.neuroimage.2014.09.016.
- • Zemmoura I; Blanchard E; Raynal PI; et al. How Klingler's dissection permits exploration of brain structural connectivity? An electron microscopy study of human white matter. Brain Struct Funct 2016; 221: 2477-2486. 2015/04/24. DOI: 10.1007/s00429-015-1050-7.
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