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Develop new strategies in photodynamic therapy to treat cancer and infectious diseases.
Taiwan (FMS-Taiwan) - National Cheng Kung University, Tainan
Department of Dermatology, Biochemistry & Molecular Biology, Center of Applied Nanomedicine
Dr. Tak-Wah Wong (Ken) MD, PhD
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Photodynamic therapy (PDT) comprises of the selective activation of a photosensitizer in a cell with a specific wavelength of light. It has become a new treatment for non-melanoma skin cancers and different skin diseases. Recently, PDT has been explored in clinical applications in wound healing and infections. We found for the first time that PDT can alter antibiotic-resistant Staphylococcus aureus into a more sensitive phenotype and promotes wound healing via cystic fibrosis transmembrane conductance regulator (CFTR) protein.
What is the aim of the project?
We are exploring new strategies to enhance PDT efficacy in treating cancer, infectious diseases and wound healing.
What techniques and methods are used?
We will carry out in vitro experiments for instances, cell culture, skin organ culture, bacterial cultures, drug sensitivity tests, immunohistochemistry, polymerase chain reaction (PCR), reverse transcription polymerase chain reaction (RT-PCR), Western Blot as well as animal (mice) study. Students are allowed to observe the patients’ actual condition during tutor’s clinical hours.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- If the project is clinical
- the student will be allowed to work with patients
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
During the exchange program, the student is expected to learn basic life science laboratory techniques, including using pipette, preparing buffers, solutions, and serial dilutions. The student is also expected to learn to culture bacteria cells. The student will have to attend lab meetings every week. After the student has mastered basic laboratory techniques, he or she will co-design an independent research project with the Principle Investigator and submit a final report or poster at the end of the program.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The program doesn’t require any theoretical teachings. However, the student is encouraged to read research articles related to the research project and participate in lab meetings.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
There is no preliminary laboratory techniques required for the lab.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Wong; T. W.; et al. (2019). "Indocyanine Green-Mediated Photodynamic Therapy Reduces Methicillin-Resistant Staphylococcus aureus Drug Resistance." J Clin Med 8(3).
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