Induction of differentiation of glioma by small molecules and the mechanisms.
China (IFMSA-China) - Soochow University, Suzhou
Department of Cell Biology
Huanxiang Zhang
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No Yes Yes Yes Yes No No No
Type of Research Project
- Basic science
What is the background of the project?
Glioma is a deadly primary central nervous system tumor, originates most often from the glial cells of the brain and exhibits invasive proliferation of brain tissue and has an extremely poor prognosis. One potential therapeutic approach is to induce the terminal differentiation of glioma. The differentiation of tumor cells is efficiently induced by different combinations of small molecules, so that tumor cells exit the cell cycle, reducing their proliferation and metastasis ability, and the differentiation mechanism should be elucidated.
What is the aim of the project?
The purpose of this project is to provide strategies for the treatment of glioma
What techniques and methods are used?
1. Culture of glioma cells 2. Immunocytochemistry 3. Real-time Quantitative Polymerase Chain Reaction 4. Construction of mouse glioma model
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
To follow laboratory activities associated to the specific perform in very simple lab tasks. To participate in weekly lab meeting, reporting, weekly activities.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Good basis of scientific knowledge minimum experience in laboratory practice high attitude for team work.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Students in biomedical fields
- Jing Liu; Youhua Wei; Yebing Chen; Xiaojing Xu; Huanxiang Zhang*. Differentiation of Neural Stem Cells Influences Their Chemotactic Responses to VEGF. Journal of Neuroscience Research; 2011(89): 1173-1184.