Projects
Name
Neuronal and glial autophagy in alzheimer’s disease: L1CAM-mediated autophagy in the pathogenesis of Alzheimer’s disease.
University
China (IFMSA-China) - Soochow University, Suzhou
Domain
Neurology
Departement
Institute of neuroscience
Head
Tutor
Quan-Hong Ma
Languages
English, Chinese
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes Yes No No No No
Type of Research Project
- Basic science
What is the background of the project?
Alzheimer’s disease (AD) is a neurodegenerative disorder charaterized with cognitive deficits. Autophagy is impaied in the brains of AD patients. However, how autophagy is dysregulated and contributes to the AD pathogenesis remains unclear. The project is trying to understand how neuronal autophagy and glial autophagy regulates the pathogenesis of AD.
What is the aim of the project?
The project is trying to understand how neuronal autophagy and glial autophagy regulates the pathogenesis of AD. Through this project, we expect to find novel drug targets of AD.
What techniques and methods are used?
Immunofluoresence staining, western blot, qPCR, behavior tests
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
To learn the basic technique used in the labs; to have a general understanding the pathogenesis of Alzheimer’s disease
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student needs to read some research article related to Alzheimer’s disease and autophagy in order to have an basic understanding on the pathogesis of Alzheimer’s diease and how autophgay is involved in. Prof. Ma will help the student during this process and give some lectures when it is necessary.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
- The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Reading; None
Are there any legal limitations in the student’s involvement
No
Hours
8
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Pre-Medical students from the American-British system
- Students in biomedical fields
- Dental medicine students (IADS members)
Articles
- Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer's disease as a mitophagy receptor.
- Autophagy Dysfunction in Alzheimer's Disease: Mechanistic Insights and New Therapeutic Opportunities.