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Pharmacological characterization of different GABA and GLUTAMATE receptors modulators
Serbia (IFMSA-Serbia) - University of Belgrade, Belgrade
Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade
Nevena Divac MD, Phd Prof
Janko Samardzic MD, PhD, Ass. Prof.
Type of Research Project
- Basic science
What is the background of the project?
Pharmacological studies have fostered the development of new ligands acting through GABA and glutamate receptors with potential use in anxiety, depression and cognitive disorders. On the grounds of our previous results, this project will assess the behavioral profiles and molecular mechanism of action of different GABA and glutamate receptors modulators: from minerals (magnesium-Mg) and endogenous substances (dehydroepiandrosterone-DHEA) to drugs: such as those selectively acting through alpha1 subunit-containing receptors as positive allosteric modulator (PAM, zaleplon) and those selective for alpha5 receptors as negative allosteric modulators (NAM, L- 655,708), following acute and repeated administration in rats.
What is the aim of the project?
The proposed investigations would provide the important sets of information: 1. What are the differences and similarities between effects on behavioral and molecular outcomes after application of three classes of psychoactive substances: minerals (Mg), endogenous substances (DHEA) and drugs (zaleplon, L-655,708)? 2. To what extent do behavioral effects depend on GABA or glutamatergic receptor modulation, as well as what is the link between the observed behavioral change and receptor subunit composition? 3. To what extent do behavioral effects following acute and repeated administration of alpha1 and alpha5 selective ligands differ from those elicited by standardpsychopharmacologic drug? These sets of data could bevaluable for pharmacological, neurological and psychiatric expertise, such as more successful creation of new psychoactive drug candidates.
What techniques and methods are used?
The research is planned to be performed in two blocks of experiments. The first part will comprise the behavioral and molecular studies with minerals (Mg) and endogenous substances (DHEA) and respective antagonists, while the second would address activities with zaleplon and L- 655,708. Each block, will include various tests of unconditioned behavior:spontaneous locomotor activity test (SLA), elevated plus maze (EPM) for testing anxiolyticlike effects of substances, forced swim test (FST)for testing antidepressant-like effects and active avoidance paradigm (AA)for testing drug effects on cognitive function, as well as subsequent molecular studies. All these tests are wellestablished in neuroscience and published by our groups.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
What are the tasks expected to be accomplished by the student?
The student will observe some practical pharmacological experiments and will be highly involved in the analysis of the results, scientific writing and journal clubs.Moreover, the project will influence the development of new research groups in the field of psychoactive substances investigations and improvement of professional capacities of students and young scientist.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminary readings and seminars, including a shortlaboratory safety training, provided by tutor.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Higlhy motivated in neuroscience.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Students in biomedical fields
- Samardzic J; editor. GABA and Glutamate - New Developments In Neurotransmission Research; IntechOpen; 2018.
- Samardzic J; Borovcanin M; Dukic-Dejanovic S; Jancic J; Duric M; Obradovic DI. In vivo methodology in behavioural pharmacology - where are we now? Vojnosanit Pregl. 2017; 74(4):354-360.
- Samardzic J; Svob Strac D. Benzodiazepines and anxiety disorders: from laboratory to clinic. Book chapter in Anxiety Disorders; Ed. Durbano F; InTech; 2016.
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