Pediatric Cancer - Children and Adolescent’s Health Provide genetic carrier family with genetic counseling
Brazil (IFMSA-Brazil) - Faculdades Pequeno Principe (FPP), Curitiba
Applied Biotechnology to children and Adolescent health Department
Rosiane Guetter Mello
Rosiane Guetter Mello
Required: english or portuguese; Accepted: spanish and italian
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
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Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Since 2004, the Institute Pelé Pequeno Príncipe researches a specific genetic mutation that is four hundred times more frequent in Brazil in comparison to other countries throughout the world. Such mutation is named R337H, its carrier has 33% more chances to develop adrenal cortex cancer up to the age of five. During life, the genetic carrier also has more chances to develop distinct types of tumors. Therefore, the research team created, after years of research, such a test which predicts whether one has such mutation. Our team also works closely to those who have such mutation. Currently, our team keeps track of and accompanies clinically 250 families. At present, this is the largest cancer Cohort Study worldwide.
What is the aim of the project?
Provide genetic counseling and clinical support to those who carry the gene mutation
What techniques and methods are used?
Research team is multiprofessional and includes biomedical scientist, nurses, physicians who work together interviewing asking about previous medical record (including tumors) and performing physical examination. The next step is to check laboratoty exams and pathology exams including biopsy if necessary. Those pacients are chosen due to the fact that a kid’s family was affected by a specific type of cancer. Afterwards, gathering all clinical and laboratory information, the research team have a group discusstion, in order to decide which conduct is best for the patient.
What is the role of the student?
- The student will mainly observe
- If the project is clinical
- the student will be allowed to work with patients
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The incoming Student is expected not only to be fully grounded of the topics dicussed by reading given articles, but also take part in the group discussion (which will be in english). Those meeting may vary in length, days and topics. If any lecture is given, it will be performed in english Student may check microscope slides in order verify the diagnosis given by the especialist. The student may also be asked to check lab results as well in order to give the student a glampse of what has been disscussed or what will be.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Students will not attend to classes, however theorical teaching will be given thoughout clinical groups discussion and oriented article reading.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Subjects passed: citology, histology, biophysics, biochemistry, anatomy, semiology. Basic biomedical knowledge.
Are there any legal limitations in the student’s involvement
Students will not be allowed to perform any procedure by their own due to IPP ethics code.
Type of students accepted
This project accepts:
- Medical students
- Pre-Medical students from the American-British system
- Students in biomedical fields
- Custódio; Gislaine; et al. "Impact of neonatal screening and surveillance for the TP53 R337H mutation on early detection of childhood adrenocortical tumors." Journal of Clinical Oncology 31.20 (2013): 2619.
- Figueiredo; Bonald C.; et al. "Penetrance of adrenocortical tumours associated with the germline TP53 R337H mutation." Journal of medical genetics 43.1 (2006): 91-96.