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Retrospective evaluation of patients who underwent haploidentic bone marrow transplantation
Turkey (TurkMSIC) - Erciyes University, Kayseri
Erciyes University Medical Faculty, Department of Pediatric Hematology Oncology,38030 Melikgazi, Kayseri, TURKEY
Associate professor Ekrem Unal,MD
Associate professor Ekrem Unal,MD
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Bone marrow transplantation, also caled hematopoetic stem cell transplantation (HSCT) is the only curative option in stem cell depleting pathologies, since peripheral blood and umbilical cord blood can also be used as sources of stem cell currently. In children, bone marrow transplantation is used as a definite treatment method in many diseases including hemoglobinopaties, immune deficiencies, bone marrow failure and congenital metabolic diseases in addition to hematological malignancies. In addition to the underlying disease, the most important factors which have an impact on prognosis include infections which develop during the process of transplantation and graft-versus-host disease (GVHD). If a full-match donor cannot be found, incompatible transplants can be made from parents or siblings. These ‘’incomplete’’ match HSCT’s are called ‘’Haploidentical HSCT’s’’ In this retrospective study, we plan to screen records haploidentic transplantations in our department for post-op complications, first and foremost the incidence of GVHD and associated negative outcomes. Turkish literature is lacking in this regard, and our research may prove invaluable for planning future emergency HSCT's.
What is the aim of the project?
Defining the incidence of post op complications of haploidentical HSCT’s in Turkey, so that these emergent and critical operations can be done with more intricate planning in the future.
What techniques and methods are used?
The clinical records of patients who undervent haploidentical HSCT in our hospital and in several other major centers will be pooled into SPSS 26 (statistical package for social sciences). Afterwards they will be compiled into ‘’pre-op, operational, immediate post-op, late post-op’’ groups. These will be subjected to further biostatistical anaylsis.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student is expected to; - Attend lectures of the tutor - Help sort the data from different patients and centers - Observe the biostatistical analysis process - Provide a report of their activities weekly to the tutor
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There will be courses about; - Bone marrow Transplantation in modern medical practice - Hemoglobinopathies - Pathophysiologies of Immune defiencies given by Associate professor Ekrem Unal,MD once a week.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No spesific skills required.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Pérez-Martínez A; Ferreras C; Pascual A; Gonzalez-Vicent M; Alonso L; BadellI; Navarro JMF; Regueiro A; Plaza M; Hurtado JMP; Benito A; Beléndez C;Couselo JM; Fuster JL; Díaz-Almirón M; Bueno D; Mozo Y; Marsal J; López AG; Sisinni L; deHeredia CD; Díaz MÁ. Haploidentical transplantation in high-risk pediatric leukemia: A retrospective comparative analysis on behalf of the Spanish WorkingGroup for Bone Marrow Transplantation in Children (GETMON) and the Spanish Grupo for Hematopoietic Transplantation (GETH). Am J Hematol. 2019
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