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Development of stem cell based therapeutic approches for various diseases
KMSA (Korea) - Gachon University, Incheon
Department of Molecular Medicine
Cheol Soo, Choi
In Sun, Hong, PhD
Type of Research Project
- Basic science
What is the background of the project?
Mesenchymal stem cells (MSCs) have shown significant therapeutic potential for tissue regeneration because of their ability to stimulate angiogenesis and migration and to promote the differentiation and growth of local progenitor or stem cells. More importantly, MSCs are recruited to damaged or diseased sites in response to various danger signals and subsequently promote tissue regeneration. However, the mechanisms by which MSCs are recruited to the sites of tissue damage and mediate multiple beneficial effects remain unclear.
What is the aim of the project?
Development of various methods or drugs to enhance the therapeutic effects of MSCs by increasing their multiple beneficial functions, such as growth, migration, and trans-differentiation potential.
What techniques and methods are used?
Firstly, students will isolate and culture human stem cells. Then they will practice in vitro cell migtration assay, cell proliferation assay and immunofluorescent staining using human stem cells. Also they will use tools MSC labeling and tracking in mouse model to experiment about therapeutic effects of MSCs. In addition, students will detect and measure characteristics of cells through flow cytometry. At the end, western blotting and PCR will be used.
What is the role of the student?
- The student will mainly observe
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Students will acquire the knowledge of various basic biogical experiments and principles of various stem cell based therapeutic approaches. They can also acquire basic knowledge of various animal based stem cell researches. Also, Students will practice diverse experiments using stem cells, such as culture of human stem cells, cell migration assay, immunofluorescent staining, MSC labeling and tracking in mouse model and so on. They will analyze data from experiments and make a new hypothesis in stem cell researches. They will write and discuss about their results.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
We will not provide lectures, courses, seminars. But graduate students will provide basic knowledge about molecular biology.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Students do not have to know special skills, but knowledge about experimental skills such as cell culture, cell migration assay, cell proliferation assay, and immunofluroscent assay would be helpful.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Cho A; Park SR; Kim SR; Nam SY; Lim S; Park CH; Lee HY; Hong IS; An endogenous anti-aging factor; sonic hedgehog (SHH); suppresses endometrial stem cell aging through SERPINB2. Mol Ther. 2019 Jul 3;27(7):1286-1298 [IF=8.402]
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