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Evaluation of Clinicopathological Parameters in Patients with Cervical SIL (Squamous Intraepithelial Lesion)
Turkey (TurkMSIC) - Ufuk University, Ankara
Department of Pathology,Ufuk University Faculty of Medicine, Kizilirmak,Ufuk University Street No:2, 06510, Ankara/Turkey
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Please, provide the background of the project (Provide information about the project; min. 10 lines, max. 25 lines) Cervical cancer is the third most common cancer in the world after breast and colorectal cancers. Cervical Squamous Intraepithelial Lesion (SIL) is the abnormal growth of squamous cells on the surface of the cervix. Pap (A procedure in which is a small brush is used to gently remove cells from the cervix so these cells can be checked under a microscope for cervical cancer or cell changes.) tests can detect precancerous or cancerous conditions by collecting cells from the surface of the cervix. Sometimes these cells might appear abnormal, or atypical, when looked at under a microscope, but they are not completely cancerous. These are called precancerous cells. These precancerous lesions are commonly called cervical intraepithelial neoplasia (CIN) or squamous intraepithelial lesions (SIL) and there are two types: Low-grade and High-grade SIL. This research will compare the different microscopic and virologic results of materials which is previously diagnosed with cervical SIL. It will be a retrospective file analysis. Also, in Turkey we have Turkish Society of Pathology established in 1966. Society has 7 researchers. They work via concerning cancer types.
What is the aim of the project?
Observing cervical SIL cell parameters and their changes during a course of 5 years, as well as differentiating between precancerous and cancerous cells
What techniques and methods are used?
What techniques and methods are used? Mention the steps/stages in this project. (Provide examples and avoid abbreviations; which tools will be used in general in this project?) Every material which is previously diagnosed with cervical SIL will be evaluated from different ways to observe parameters. -Use X-Ray for observing material Radiology: The medical specialty concerned with radiation for the diagnosis and treatment of disease, including both ionizing radiation such as X-rays and nonionizing radiation such as ultrasound. Also known as roentgenology -Microscopic analysis is the main method in this project. The microscope is an extremely useful instrument in the examination of physical evidence. Most common is the optical microscope. With experience, a forensic microscopist can determine many specimens including glass, fibers, hair, paint chips, minerals, food particles, and more and can also run small chemical identifications and spot tests. -Statistical Package for the Social Sciences (SPSS) 26, statistical analysis, data management (case selection, file reshaping, creating derived data) and data documentation (a metadata dictionary is stored in the datafile) are features of the base software.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
What are the tasks expected to be accomplished by the student?
What are the tasks expected to be accomplished by the student? (Minimum 10 lines, provide detailed explanation) The following tasks are expected to be accomplished by the student: -The student will review and study microscopic slides, determine many specimens including glass, fibers, hair, paint chips, minerals, food particles, and more and can also run small chemical identifications and spot tests. -Reviewing the morphological analyses of cervical SIL specimens alongside Prof. Umudum as part of lectures on pathology research procedures that use malignant cells and immunohistochemistry. -He/she may help data record and data analysis Learning Statistical Package for the Social Sciences (SPSS) 26, statistical analysis, data management (case selection, file reshaping, creating derived data. -And the student will take part in retrospective file review. Learning how we use X-Ray for observing material medical specialty concerned with radiation for the diagnosis and treatment of disease.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Will there be any theoretical teaching provided for the student (preliminary readings, lectures, courses, seminars)? Please describe how much teaching and by whom. There are many different subjects open for understanding methods. The subject will be taught once per week by tutor Prof.Dr.Haldun UMUDUM depending on the availability of the teacher: -Explaining data programs for clinical findings with Statistical Package for the Social Sciences (SPSS) 26, statistical analysis, data management (case selection, file reshaping, creating derived data) and data documentation (a metadata dictionary is stored in the datafile) are features of the base software. -İnstruct microscopic techniques for slides. The microscope is an extremely useful instrument in the examination of physical evidence. -İndicate X-Ray for observing material medical specialty concerned with radiation for the diagnosis and treatment of disease. -Pathology research that includes the use of immunohistochemical staining techniques, with the use of cervical SIL specimens as examples.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No specific skills are required.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Acta Cytol. 2019;63(1):44-49. doi: 10.1159/000494984. Epub 2018 Dec 5. Three-Tiered versus Two-Tiered Classification of Squamous Dysplasia in Cervical Cytology: Results of a Follow-Up Study. Marquardt K1; Ziemke P2; Neumann K3.
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