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Clarify the mechanism of diabetes mellitus and its complications
Japan (IFMSA-Japan) - Shiga medical university, Shiga
Section of Stem Cell Biology and Regenerative Medicine, Department of Biochemistry and Molecular
Hideto Kojima MD.
Hideto Kojima MD.
Type of Research Project
- Basic science
What is the background of the project?
-Pathogenesis of diabetes mellitus and its complications using animal models and patients. -Gene therapy for various diseases such as type 1 DM, ALS, bone disease, neurological disorder, genetic disease. -Regenerative medicine using stem cells and their treatment for spinal cord injury, DM, burn, gangrene, genetic disorder. -Generating cell specific drug delivery system using phage display system and its clinical application. -Human treatment using bone marrow stem cells. -The mechanism of the onset of diabetes mellitus is still unknown. Although the hyperglycemia itself is related to the progression of the disease, the locus of the genetic background is not clarified. We are working on this topic using bone marrow transplantation model animals to find out the pathogenic lesion.
What is the aim of the project?
Development of new treatment for diabetes mellitus both type1 and type2.
What techniques and methods are used?
-Developing gene therapeutic vectors (viral and nonviral) -Animal experiments We have been using viral vectors such as helper-dependent adenovirus, lentivirus, adeno-associated virus, and non-viral vectors such as nano-diamond or polyamines. We always compared the efficiency of the vectors in specific analysis.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
-Help research of a researcher or a graduate school student. -Learn many things about basic medical research. The task of the students is not to obtain the methods only, but to understand the reason why the therapy is useful for the regenerative medicine in all medical field. Specifically we are generating a new drug delivery system (DDS) for the next generation after molecular targeting DDS. -Present the research result in a conference. -Plan a study protocol/design of animal study -Learn Japanese customs. -Communicate many specialist such as Dr, Ns, nutritionist, students, research assistants. -Learn about works for animal studies. -Learn about analyses for tissue samples. -Learn about the method for bone marrow transplantation in mouse. -Lear how to obtain stem cells.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There will be course lectures and seminars. The teaching is done by many teachears including Hideto Kojima regulary once per week.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Animal handling (sometime animal is killed for analysis)
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Emerging roles of hematopoietic cells in the pathobiology of diabetic complications. Kojima H; Kim J; Chan L; Trends Endocrinol Metab. 2014 Apr;25(4):178-87.
- NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Kojima H; Fujimiya M; Matsumura K; Younan P; Imaeda H; Maeda M; Chan L. Nat Med. 2003 May;9(5):596-603. Epub 2003 Apr 21.
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