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Propagation pathways of epileptic discharges of brain
Turkey (TurkMSIC) - Balikesir University , Balikesir
Balikesir University, Department of Physiology, Faculty of Medicine, Cagis Campus, Bigadic Road 17. Km,10440, Balikesir/Turkey
Assoc.Prof.Dr.Haydar Ali ERKEN
Type of Research Project
- Basic science
What is the background of the project?
Please, provide the background of the project (Provide information about the project; min. 10 lines, max. 25 lines) Fifty million people in the world have epilepsy, and there are between 16 and 51 cases of new-onset epilepsy per 100,000 people every year. A community-based study in southern France estimated that up to 22.5% of patients with epilepsy have drug-resistant epilepsy. Despite many antiepileptic drugs, up to 30% of patients with epilepsy can not be treated. Approximately 60% of these patients are candidates for resective surgery. Patients who are not suitable for resective surgery, vagus nerve stimulation, a form ofneuromodulation therapy, may provide additional benefit in combination with medical treatment that is greater than 50% reduction in seizure frequency. Another form of neuromodulation is deep brain stimulation. Despite all these treatment methods, not all epilepsy patients can be treated. If propagation pathways of epileptic discharges can be mapped better, all therapies of epilepsy can be revised. TURKISH CHAPTER OF INTERNATIONAL LEAGUE AGAINST EPILEPSY has been established in 1973 and has 7 members in its Board of Directors. In Turkey there are about 700.000 epileptic patients. In our university our physiology specialists have acces to the physiology laboratuary, electroconvulsive therapy (ECT), Electroencephalogram (EEG) test, Computerized tomography (CT) scan.
What is the aim of the project?
The aim of the project is mapping the propagation pathways of epileptic discharges in the brain.
What techniques and methods are used?
1.To find that specific area in brain by stereotaxic method. 2. Intracranial microinjection by Hamilton microinjector according to stereotaxic coordinates. 3. Intracranial electrode placement according to stereotaxic coordinates. 4. Electrophysiological recording of induced epileptic discharges by data acquisition system
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will be expected to participate in experimental process of project. The tasks as below expected to be accomplished by the student (Project director will provide training about all tasks to student): 1. Preparation of laboratory animals (Rat) for experiments (Anesthesia, shaving etc.). 2. Placement of rats to the stereotaxic apparatus. 3. Placement of intracranial electrode to brain according to determined coordinates before. 4. Intracranial microinjection of epileptic agent to determined coordinates before induction of seizure. 5. Electrophysiological recording of epileptic discharges by data acquisition system. 6. Observation epileptic discharges from different brain areas on the monitor with the help of Electroencephalogram (EEG). 7. Writing experiments observations to laboratory letter. 8. Sharing/discussing own comments (If there is) about experiments or findings.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The following topics will be provided in the form of seminars by Assoc.Prof.Dr.Haydar Ali ERKEN. Lessons will be provided according to the availability of the teacher, at least once per week: General information about Epilepsy, Epileptic discharges and its recordings in rats, Stereotaxic interventions in rats, Intracranial microinjection and electrode placement in rats will be provided. (Note: The documents will be provided to the student)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student should have a Certificate of Experimental Animal Usage from their country. Previous experience with experimental research on laboratory animals is preferred.
Are there any legal limitations in the student’s involvement
The student should have a Certificate of Experimental Animal Usage from their country.
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- 1. Sander JW: The natural history of epilepsy in the era of new antiepileptic drugs and surgical treatment. Epilepsia 44 (Suppl.1): 17-20;2003
- 2. DeGiorgio CM; Schachter SC; Handforth A; et al: Prospective long-term study of vagus nevre stimulation for the treatment of refractory seizures. Epilepsia 41(9):1195-1200; 2000
- 3. Akman T; Erken H; Acar G; et al. Effects of the hippocampal deep brain stimulation on cortical epileptic discharges in penicillin - induced epilepsy model in rats. Turk Neurosurg. 2011 Jan;21(1):1-5.
- 4. Ozcelik L; Acar F; Cirak B; Suzer T; Coskun E; Tahta K; Genc O; Ali Erken H. The influence of cervical spinal cord stimulation on induced epileptic discharges in rats. Brain Res. 2007 Mar 2;1135(1):201-5. Epub 2006 Dec 26.
- 5. Erken HA; Erken G; Genç O; Kortunay S; Sahiner M; Turgut G; Turgut S. Orexins cause epileptic activity. Peptides. 2012 Sep;37(1):161-4. doi: 10.1016/j.peptides.2012.06.012. Epub 2012 Jul 4.
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