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Prognostic Genetic and Clinicopathologic Factors in Early Stage Operated Lung Cancer Patients.
Turkey (TurkMSIC) - Istanbul University Cerrahpasa Medical Faculty, Istanbul
İstanbul University-Cerrahpasa Cerrahpasa Medical School Department of Thoracic Surgery Cerrahpasa, Koca Mustafapasa Cd. No:53 34096 Fatih/Istanbul
Akif Turna, MD, PhD, FETCS
Akif Turna, MD, PhD, FETCS
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Survival curves and clinical observations confirm that generally similar patterns of biological behavior will prevail for groups of patients with lung cancer having the same disease stage and histologic type. The prognostic significance of this information has proved useful for physicians to select treatment, estimate prognosis, and compare the results of different therapies. As a source of the current staging system, revisions in the international system for staging lung cancer were proposed. In one reference series, the cumulative 5-year survival was 67% for stage IA, 57% for stage IB, 55% for stage IIA, 39% for stage IIB, 23% for stage IIIA. However, great differences in outcome after resection have been currently observed in patients with the same stage. Although various histologic prognosticators have been investigated, such as tumor size or the presence of blood vessel invasion, gene mutaions they are not yet fully incorporated into the TNM (Tumor-Node-Metastasis) classification.
What is the aim of the project?
We aim to assess the prognostic value of clinicopathological parameters such as blood vessel invasion, lymphatic vessel invasion, and perineural invasion, gene mutations as well as that of clinical and histopathologic data.
What techniques and methods are used?
The database of this research contains the data of more than 720 patients who had undergone resectional surgery for early stage non-small cell lung cancer. So the students will participate in the analysis of these parameters. They will also be required to redo some of the clinical examinations.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project is clinical
- the student will take active part in the clinical examination
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
- Recording of preoperative and postoperative genetic and clinicopathologic parameters of the patients into the dedicated database. - Recording of survival data of the patients(i.e.follow-up information). - Entry of the missing clinicopathological parameters into the database - Improvement of the created figures, tables and illustrations regarding the study. - Summarizing of the evaluated data - Observering during article writing process and learning the article writing processes.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes: Lectures regarding article writing, evaluation (By Akif Turna, MD: 1 week course),Data entering to lung cancer database
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No spesific skills are required.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- D’Amico TA; Massey M; Herndon JE; Moore MB; Harpole DA. biologic risk model for stage I lung cancer: immuno- histochemical analysis of 408 patients with the use of ten molecular markers. J Thorac Cardiovasc Surg 1999;117:736– 43. https://doi.org/10.1016/S0022-5223(99)70294-1
- D’Amico TA. Molecular biologic substaging of non-small cell lung cancer. J Thorac Cardiovasc Surg 2002;123:409–10. https://doi.org/10.1067/mtc.2002.120339
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