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Screening of Galanin Expression in The Thyroid cancers
Turkey (TurkMSIC) - Firat University, Elazig
Firat University, Faculty of Medicine, Department of Medical Biochemistry 23119, Turkey/Elazig
Prof. Dr. Suleyman Aydin
Assistant Prof. Dr. Ramazan Fazil Akkoc
Type of Research Project
- Basic science
What is the background of the project?
Please, provide the background of the project (Provide information about the project; min. 10 lines, max. 25 lines) Thyroid cancers represent approximately 1% of new cancer diagnoses each year and its incidence has been continuously increasing. Screening of Peptide and Protein in cancer tissues recently is a hallmark of diagnosis of cancer. According to the data of “Turkey Endocrinology and Metabolism Society”, the second most common cancer type in Turkey is Thyroid cancer. This is why its important to make this study. “Turkey Endocrinology and Metabolism Society” is a society that is established in 2018. This society does various actions (like congress and educational courses) about endocrinological and metabolism diseases that also contains Thyroid cancer. In our university’s department there are currently 12 Medical Biochemistry specialists working.
What is the aim of the project?
The main objective of this study is to investigate galanin expression in various thyroid pathologies and to compare these expression patterns with galanin expression in healthy thyroid tissues.
What techniques and methods are used?
The study groups will be consisted of 30 cases each of control thyroid tissue, Hashimoto's thyroiditis, thyroid papillary carcinoma, oncolytic papillary carcinoma, follicular thyroid carcinoma, oncocytic follicular thyroid carcinoma, medullary thyroid carcinoma, anaplastic thyroid carcinoma. Those tissues will be obtained from Pathology Archive of Firat University. Galanin expression will be screened by using immunohistochemistry. Galanin levels in thyroid tissue supernatants will be measured using ELISA (Enzyme-Linked ImmunoSorbent Assay). Usage of Statistical Package for the Social Sciences (SPSS) 26 for the analysis of the project results.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The following tasks are expected to be accomplished by the student: -Observing and examining the steps and process of the ELISA (Enzyme-Linked ImmunoSorbent Assay) technique -Investigating the relationship between healthy and pathological thyroid tissues with the use of immunohistochemistry techniques and the help of the supervisor -Working actively in the data collection process - Learn and use of Statistical Package for the Social Sciences (SPSS) 26, statistical analysis, data management (case selection, file reshaping, creating derived data) and data documentation to analyze the results of the project.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
A theoretical course about thyroid cancer will be given once by Prof. Dr. Suleyman Aydin according to the availability of the teacher.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No spesific skills are required.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Ugur K; Aydin S; Kuloglu T; Artas G; Kocdor MA; Sahin I; Yardim M; Ozercan IH. Comparison of irisin hormone expression between thyroid cancer tissues and oncocytic variant cells. Cancer Manag Res. 2019 Mar 28;11:2595-2603.
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