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(Timisoara) Biochemical mechanism of human-microbiota interactions
Romania (FASMR) - University of Medicine and Pharmacy "Victor Babes", Timisoara
Biochemistry Dept, University of Medicine and Pharmacy “Victor Babes”
Prof.Dr. Andrei Anghel
Prof.Dr. Andrei Anghel
Type of Research Project
- Basic science
What is the background of the project?
The project intends to investigate the correlation between the human organism and the skin microbiota. The skin microbiota, a part of the human microbiome, plays an important role in the human body by being in direct contact with the enviroment microbiome. As a result any skin lesion changes the whole dynamic between the skin and enviroment microbiota, leading to a new relationship between human and skin microbiome. To establish the skin microbiota profile in different skin diseases is essential for prognostic and targeting therapy. The project evaluates different topic formula of prebiotics, probiotics and postbiotics possible to use for normal skin microbiota restauration.
What is the aim of the project?
The aim of the study is to identify the specific profile of microbiota in different skin diseases.
What techniques and methods are used?
We will use modern technics, such as total Ribonucleic acid (RNA) extraction,selection of small microRNA and Next-Generation Sequencing (NGS) methods. Firstly, the samples will be prepared. This step prepares RNA samples to be compatible with a sequencer. Secondly, the RNA fragments are placed on the sequencer and amplified, resulting millions of copies. Thirdly, after the sequencing a data analysis will be made and results will be interpreted. The biological samples will be provided by the University Biobank.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The students will have to research about the topic of the project and read the articles provided by the tutor. The students will be provided with theoretical teaching of the used methods and explanation of the laboratory tools. Under supervision will learn how to acquire practial lab skills, such as sample preparation by pipetting and labeling biological samples. The student will learn how to use the laboratory tools. The student will learn how to analyse the resulting data. The student is expected to prepare a scientific poster regarding the results of the research.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, theoretical seminars will be provided during the practical training by the tutor.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
At least 2 years of preclinical studies Show interest in preclinical science
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Dysbiosis of Skin Microbiota in Psoriatic Patients: Co-occurrence of Fungal and Bacterial Communities Zuzana Stehlikova; Martin Kostovcik; Klara Kostovcikova; Miloslav Kverka; Katerina Juzlova; Filip Rob; Jana Hercogova; Petr Bohac; Yishay Pinto; Atara Uzan; Omry Koren; Helena Tlaskalova-Hogenova; Zuzana Jiraskova Zakostelska Front Microbiol. 2019; 10: 438. Published online 2019 Mar 21. doi: 10.3389/fmicb.2019.00438
- Skin microbiota–host interactions Y. Erin Chen; Michael A. Fischbach; Yasmine Belkaid (Nature . 2018 January 24; 553(7689): 427–436. doi:10.1038/nature25177)
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