Projects
Name
Invesgation of the effects of boron doped hydrogels on seconds degree burn healing.ct
University
Turkey (TurkMSIC) - Ataturk University , Erzurum
Domain
Pharmacology
Departement
Department of Medicsl Pharmacology, Ataturk University Faculty of Medicine,Atatürk Mh., 25240, Erzurum/Yakutiye
Head
Yasin BAYIR, Professor of Biochemistry
Tutor
Yasin BAYIR, Professor of Biochemistry
Languages
Turkish, English
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No Yes Yes No No No No No No No
Type of Research Project
- Basic science
What is the background of the project?
Burn injuries are a common and serious health problem with no definitive treatment that aims to help with tissue regeneration rather than conservative observation. The most common burn injuries are second degree burns caused by scald with hot fluids and it’s most important complication is infections. While many approaches are being exhibited for the treatment of these and similar burn wounds nowadays, each product has it’s own advantages. Our department is investigating the use of Boron augmented hydrated gels in improving regeneration of tissue after burn injuries.
What is the aim of the project?
To investigate the viability of the usage of Boron in improving bullous skin degeneration, burns, toxic epidermal necrosis, epidermolysis bullosa and pemphigus.
What techniques and methods are used?
- Effects of boron will first be analyzed in vitro using cell cultures of the HeLa line with controlled thermal injury - Antimictobial potential of boron will be tested by observing bacterial growth rates during the healing process, using the same culture lines and strains of Staphylococcus aureus, streptococcus pyogenes - Boron augmented hydrogel plasters will be applied to rats with produced thermal injuries. Healing times and infection rates will be documented - Data will be processed using Statistical Package for Social Sciences (SPSS) 26th edition and Microsoft Excel
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student will mainly observe the described processes, especially during the parts involving live rats. The main activities the student can expect to perform under supervision are: - Maintaining cell cultures and incubators - Processing the results using SPSS - Preparing slides from and observing under microscopy the cell cultures during their process of healing - Help prepare the different concentrations of Boron augmented hydrogel - Perform cytometry to determine the extent of bacterial invasion in vitro - Maintain bacterial cultures cultivated from rats to determine the extent of bacterial invasion in vivo
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There will be no lectures. But the student will be informed during the study.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No spesific skills are required.
Are there any legal limitations in the student’s involvement
No
Hours
9
Type of students accepted
This project accepts:
- Medical students
Articles
- Zuo KJ; et al. Plast Reconstr Surg 2017 - Review. PMID 28027250
- Vigani A and Culler CA. Vet Clin North Am Small Anim Pract 2017 - Review. PMID 28802983
- Palmieri TL; et al. Surg Clin North Am 2014 - Review. PMID 25085096
- Daigeler A; et al. Chirurg 2015 - Review. PMID 25894015