Medical Research Internship of Immunopathology Lab in Okayama Japan
Okayama University
Department of Pathology & Experimental Medicine
Akihiro Matsukawa
Tutor(s) Akihiro Matsukawa, Masayoshi Fujisawa, Toshiaki Ohara
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes Yes No No No No No Yes Yes Yes Yes
Type of Research Project
- Basic science
What is the background of the project?
Okayama University is designated as Super Glover University by the Ministry of Education. The medical department accepts many foreign students for clinical training, research internships, and clinical PBL sessions, and dispatches students to various countries and regions. Regarding research internships, we have a long history of accepting many students and teach them in much the same way that we handle native (Japanese students).We believe that our program is also meningful for IFMSA Students, and that’s why we decided to participate in the IFMSA exchange program. We have focused on the mechanism(s) of diseases, with special interests to inflammation and inflammation related cancer. Advances in inflammation biology appear to pave the new therapeutic strategy for the treatment of clinical inflammatory and inflammatory- associated diseases. Students will involve in the related research.
What is the aim of the project?
Learning objectives 1. To experience higher knowledge through research. 2. To understand the importance of research. 3. To learn the social culture. In order to stimulate and motivate Okayama University Student, through cultural interaction, exchanging the ideas and widening the professional perspectives with the understanding of the medical research situation in Japan. In this research project, we aim to clarify the causal relationship between cancer and inflammation, particularity, elucidating the effect of the excessive production of inflammatory cytokinesis.
What techniques and methods are used?
Cell culture, HE staining, Immunohistochemical staining, Polymerase chain reaction,Western blotting, In situ hybridization, immune-precipitation will be used to clarify the causal relationship. Immunohistochemistry (IHC) is used to detect the presence of specific protein markers that can assist with accurate tumor classification and diagnosis. Immune-precipitation is the separation of an antigen from a solution by the formation of a large complex with its specific antibody. The further detailed explanation will be given before students start the project. We will support students as much as possible to perform experiments.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
After the discussion, students will be assigned one “research project”. Of course, the staff will support you, but at the same time you need to be responsible for the project. Learning outcomes 1. Students can perform research with understanding the significances and the purposes of their research. 2. Students can read the articles related to their research. 3.Students can perform basic experiment. 4. Students can discuss about the contents and the results of their research. 5. Students can deliver the presentations about the plan and the results of their research. 6. Students can consider their career path and future image of a doctor or some specialost in medical or biological fields.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Students can get the articles and thesis they need before arrival. Students are required to attend a study group or journal club during their stay.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
- The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Students need to have appropriate communication skills in English, including basic scientific or medical terms.
Are there any legal limitations in the student’s involvement
If yes, what are the limitations? Theare are some possibitities that student can’t treat animals by their own due to the rules of animal ethics.
Type of students accepted
This project accepts:
- Medical students
- Yang X; Fujisawa M; Yoshimura T; Ohara T; Sato M; Mino M; San TH; Gao T; Kunkel SL; Matsukawa A Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα. Sci Rep. 2018 9;8(1):188.
- Yang X; Fujisawa M; Yoshimura T; Ohara T; Sato M; Mino M; San TH; Gao T; Kunkel SL; Matsukawa A Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα. Sci Rep. 2018 9;8(1):188.
- Zhang W; Wu Y; Shiozaki Y; Sugimoto Y; Takigawa T; Tanaka M; Matsukawa A; Ozaki T. miRNA-133a-5p Inhibits the Expression of Osteoblast Differentiation-Associated Markers by Targeting the 3' UTR of RUNX2. DNA Cell Biol. 2018Yoshimura; T. The chemokine MCP-1 (CCL2) in host interaction with cancer.A foe or ally? Cell. Mol. Immunol. 2018.