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Mechanisms and role of regulatory peptides in gastrointestinal integrity and protection
Poland (IFMSA-Poland) - Jagiellonian University, Krakow
Department of Physiology Faculty of Medicine Jagiellonian University Medical College
prof. Tomasz Brzozowski
dr Marcin Magierowski, dr Sławomir Kwiecień
Type of Research Project
- Basic science
What is the background of the project?
Gaseous molecules are significant in protection of GI-tract due to their effect on blood flow and generation of reactive oxygen species (ROS). The physiological factors such as peptides can interact with gaseous mediators to influence these mechanisms. Our studies have revealed that gaseous mediators such as nitric oxide (NO), hydrogen sulfide (H2S) and carbon monoxide (CO) are capable of inhibiting the development of gastrointestinal lesions and they accelerate the healing of chronic gastric ulcers. The major mechanisms involve the enhancement in gastrointestinal microcirculation, the inhibition of proinflammatory factors including cytokines and the activation of antyoxidizing biomarkers: superoxide dismutase (SOD) and gluthatione peroxidase (GPx).
What is the aim of the project?
The aim of the project is to determine whether regulatory peptides can influence the generation of gaseous mediators - nitric oxide, hydrogen sulfide and carbon monoxide.
What techniques and methods are used?
The student will learn basic laboratory techniques with a IFMSA International Secretariat, c/o IMCC, Nørre Allé 14, 2200 København N., Denmark used? Mention the steps/stages in this project. (Provide examples and avoid abbreviations; which tools will be used in general in this project?) possibility to work in the team of researchers. She/he will observe experimental techniques in molecular medicine. We will use the following tools: blood flow meter, kits for ROS: Malondialdehyde (MDA), reduced glutathione (GSH), SOD, GPx, kits for mRNA proteins expression.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
During our scientific project student will be actively enrolled in various procedures. He/she will learn basic laboratory techniques (data analysis and calculations, preparation of solutions, homogenization of tissues, weighing of chemicals). Student will have the possibility to work with the team of researchers and will be provided with all necessary directions. She/he will observe experimental techniques in molecular medicine and procedures involving animal subjects.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, we will provide students with study contents and our publications.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
basic laboratory procedures: weighing of chemicals, preparations of solutions, calculation of the data, homogenization of tissues. Previous experience with: calculation of the data but this is not mandatory
Are there any legal limitations in the student’s involvement
During animal experimentations observing only!
Type of students accepted
This project accepts: - Medical students - Students in biomedical fields - Dental medicine students (IADS members)
- Exploiting Significance of Physical Exercise in Prevention of Gastrointestinal Disorders. PMID: 29788876
- 2)Time-dependent course of gastric ulcer healing and molecular markers profile modulated by increased gastric mucosal content of carbon monoxide released from its pharmacological donor. PMID: 30753813
- 3) Helicobacter pylori-activated gastric fibroblasts induce epithelial-mesenchymal transition of gastric epithelial cells in vitro in a TGF-β-dependent manner. PMID: 31411795
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