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Prevalence, adverse drug reactions and factors associated with the use of over-the-counter nonsteroidal anti-inflammatory drugs in a locality of north to Perú.
Universidad Nacional de Piura
Department of Public Health, Faculty of Health Sciences, National University of Piura,
Dr Victor Raul Ocaña Gutierresz MSc/Dr.
Dr Victor Raul Ocaña Gutierresz MSc/Dr.
Type of Research Project
- Basic science
What is the background of the project?
Pain is the most consulted symptom in primary care, estimating its presence in more than half of medical consultations, which significantly affects the quality of life of patients, transcending their family, work and social environment. Among the different pharmacological and non- pharmacological methods, non-steroidal anti-inflammatory drugs, which are among the most commonly used drugs worldwide, are the first-line drugs in the fight against pain; This group includes the use of Naproxen, Ibuprofen, Diclofenac and Paracetamol as a preference among patients. Nonsteroidal anti-inflammatory drugs (NSAID) are the most common type of medications used in self- medication, representing the main cause of drug-related morbidity, this practice may be representing more than 80% of the times to treat pain and fever. A study on the use of non-steroidal analgesics and anti- inflammatories in rural population, found that 1 in 4 patients come to repeat prescriptions does so in order to request an NSAID; This could be an explanation because the lack of effectiveness of the treatment. Self-medication is more prevalent self-medication is the urban area and the literature mentions that people tend to self-medicate due to influences among them we have the recommendation of a technician or a television commercial. Likewise, the family is an important factor that influences consumers when practicing self- medication. Currently there are few studies in communities to know the reality of self-medication with NSAID, which is why we propose a study of this type.
What is the aim of the project?
To determine the prevalence, adverse drug reactions and factors associated with the use of over-the-counter nonsteroidal anti-inflammatory drugs in a locality of north to Perú.
What techniques and methods are used?
The present study will be carried out following the following steps: 1) Identifications of the study population: You will go house to house in the marginal urban area and you will wonder if there are people and home who “in the last month have had some pain”. 2) Data collection: The cases have been identified, the informed consent form will be requested and the Data Collections Form well be completed in a complete appropiate manner. 3) Clinical diagnosis: Patients who participated in the study and presented adverse reactions to NSAIDs will be treated by a doctor. 4) Data analysis: First, the surveys will be reviewed and those that are complete in their entirety will be selected, then they will be transferred to a Database in the exel program for microsoft windows 2010 using numerical codes. This base will be extrapolated to the statistical progran Stata version 11.1 where the statistical analysis will be carried out. For the descriptive analysis, the absolute and relative frequencies of the categorical variables studied will be determined. In addition the medians and ranges or means and standard deviations of the studied quantitative variables will be obtained, according to the evaluation of the normality of the numerical data with the statistical test of Shapiro Wilk. For inferential analysis, a 95% confidence level of the data will be used. In the bivariate statistics, p-values and crude prevalence ratios - RPc- will be obtained (with their respective 95% confidence interval -IC95%-) through the logistic regression test (if the obtained prevalence is less than 10%) or through generalized linear models with the Binomial/Poisson family plus the log link function (if the obtained prevalence is greater than 10%). For this section, the value p<0.05 will be taken into account as statistically significant. 5) The resuts: they will be written together with conclusions and recommendations in a research article that is planned to be published later in a journal.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
He will work on the collection of data house by house in the locality under the supervision of the project tutor and in the company of other members of the local association who will also participate in the project. In addition, the student will receive training by the tutor on the use of the Stata statistical program to perform the statistical analysis of the data as a whole. This analysis will have 2 sections: descriptive and bivariate. Finally reporting results. If the student does not speak Spanish, he will participate as an observer in some data collection sessions, together with the tutor and other local students. But their participation in data analysis and results writing will be reinforced.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Training in scientific writing and statistical analysis will be carried out by the tutor in charge of the project and scientific advisors of the local association. The statistical program that will be used will be Stata, the same one that will be provided free of charge to the student.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare an abstract - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
- Interest and motivation for field research - Basic training on research methodology - Ease of teamwork - Communication skills
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Vivanco DC. automedicación en zonas urbana y urbano- marginal en la provincia de Lima (Peru). Revista Medica Carrionica. 2018;4(1).
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