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Efficacy and toxicity of meglumine antimoniate in promastigotes of circulating species of leshmania in zone 7 of the Ecuador
Ecuador (AEMPPI) - Universidad Nacional de Loja, Loja
Global Health and Neglected Diseases
Department of Biochemistry, Isidro Ayora Hospital, National University of Loja, Ecuador
Dr Luis Morocho
Dra Loidy Zamora and Dr Luis Morocho
Type of Research Project
- Global Action Project (GAP)
What is the background of the project?
Leishmaniasis is a parasitic infection caused by different species of leishmania protozoa .In Ecuador, due to a climatic change, the vector is immigrating causing an underreporting of reported cases of cutaneous leishmaniasis. The main causes of an increase in these infections are factors such as deforestation, urbanization and poverty in the surrounding areas. Throughout these years in our country that disease has been classified as an NTD (neglected tropical diseases) since there is little interest in study by pharmaceutical companies. That is why we are interested in determining efficacy, toxicity and demonstrating a possible resistance of leishmania species to meglumine antimonate
What is the aim of the project?
determining efficacy, toxicity and demonstrating a possible resistance of leishmania species to meglumine antimonate
What techniques and methods are used?
Active search technique Localized case sample The student will help in the clinical part and the classification of possible patients with Leishmaniasis Sampling for microscopy and culture to perform molecular analysis extraction of DNA PCR / Sequencing Treatment follow-up Conduct a Study for active case search
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
In lab Work the student will analyzes samples Microscopy Laboratory cultures of Leishmania Molecular Biology procedures: extraction of DNA Basic biosecurity rules in the laboratory The student will observe the practical experiments but will be very involved in the analysis of the results by means of an analysis of the variance with a factor (ANOVA) The student will take active part in the practical aspect of the project. Anamnesis with patients Physical exam The student will take active part in the clinical examination the student will be allowed to work with patients The tasks of the student will be performed on his/her own Collection of samples Molecular Biology procedures: extraction of DNA
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Lectures Personalized Classes in Universidad Nacional de Loja , classrooms of Medicine / Laboratory (3 days)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Parasitology of Hemoflagellates Life cycle of Leshmania, clinical manifestations, recommended treatments Basic biosecurity rules in the laboratory Basic laboratory techniques Use the pipette technique Microscopy
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Students in biomedical fields
- Anderson B. Guimarães-Costa; M. T.-S. (3 de abril de 2009). Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps. Obtenido de https://www.pnas.org/content/pnas/early/2009/04/02/0900226106.full.pdf
- Ger van Zandbergen; A. B. (2009). Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum. Retrieved from https://www.pnas.org/content/pnas/early/2009/04/02/0900226106.full.pdf
- Héctor Hernán Henao; Y. O. (2016). Eficacia y toxicidad de los antimoniales pentavalentes en un modelo animal de leishmaniasis cuánea americana:. Obtenido de http://www.scielo.org.co/pdf/bio/v24n4/v24n4a08.pdf
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