Projects
Name
Diagnostic validation of clinical and functional tools to assess the level of asthma control of children.
University
Universidad San Martin de Porres
Domain
Anaesthesiology
Departement
Diagnostic validation of clinical and functional tools to assess the level of asthma control of children.
Head
Cesar Alberto Galván Calle
Tutor
Cesar Alberto Galván Calle
Languages
Spanish
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
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Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Bronchial asthma is one of the most frequent non- infectious chronic disease in Peruvian Children. According to the ISAAC study, in Peru, it is found with intermediate prevalence (20.7 to 28.2%). In this way, various tools have been developed to evaluate the level of control of bronchial asthma. The criteria of the Global Initiative for Asthma (GINA) are the most used to establish the level of asthma control; however, for its reliability, it needs to be applied by a properly trained doctor. Among other tools, we can mention the Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ) and Asthma Questionnaire in Children (AQC). These tools are basically clinical, easy to use and address the control of bronchial asthma from questions made to the patient and their adult caregiver. Given this, functional tools have been developed, such as the Exhaled Fraction of Nitric Oxide (FeNO) test, which aims to establish a level of control based on the indirect quantification of airway inflammation; and Impulse Oscillometry (IOS), that establishes an approximation to the level of control from its parameters of small airways. In Peru, the diagnostic assessment of the different tools used to establish asthma control in children has not been carried out.
What is the aim of the project?
Validate the diagnostic performance of the ACT, ACQ, AQC, impulse oscillometry and Exhaled Fraction Nitric Oxide questionnaires to establish the level of asthma control in children in relation to the GINA classification of asthma control (gold standard).
What techniques and methods are used?
Patients who meet the inclusion and exclusion criteria will be recruited during their medical consultation at the National Allergy, Asthma and Immunology Reference Center. The informed consent for the participation in the study will be made to the parents or the legal tutor. Informed consent will be given to children over 6 years of age. They will be classified according to the level of control based on the GINA criteria. The ACT questionnaire will be applied to children and guardians in the version of 4 to 11 years and if the child is older than 11 years the ACT questionnaire will be applied for children 12 years and older. The ACQ questionnaire will be applied to children and their caregivers. The AQC questionnaire will be applied in its version children and adolescents to children over 8 years, but if the child is under 8 years, we will apply the AQC questionnaire for tutors. The Asthma Knowledge test will be applied to the patient's caregiver. The Morinsky test will be applied to the patient to evaluate adherence to treatment. The questionnaires ACT, ACQ, AQC, Knowledge Test of Asthma to the Caregiver, and the Morinsky Green test have been previously validated to Spanish in other studies and the exact version will be used of each one of these for the realization of the present study. All data will be collected in a previously designed data collection form (Annex 1). After completing the data, the Exhaled Nitric Oxide Fraction test will be performed, a spirometry test to determine the FEV 1 and then an Impulse oscillometry. Approximately all the tests will take 60 minutes.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Explain in detail to patients and legal guardians the procedures involved in the study and encourage them to participate in it by signing and filling the informed consent. Collect information of patients through the questionnaires ACT, ACQ, AQC, Knowledge Test of Asthma to the Caregiver, and the Morinsky Green test. See the performance of the clinical procedures and according to the student knowledge carry out functional tests.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Explain in detail to patients and legal guardians the procedures involved in the study and encourage them to participate in it by signing and filling the informed consent. Collect information of patients through the questionnaires ACT, ACQ, AQC, Knowledge Test of Asthma to the Caregiver, and the Morinsky Green test. See the performance of the clinical procedures and according to the student knowledge carry out functional tests.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student will prepare a presentation
- The student will prepare a scientific report
- The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Encouragement to learn
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
Articles
- Dinakar C; Chipps BE; SECTION ON ALLERGY AND IMMUNOLOGY; SECTION ON PEDIATRIC PULMONOLOGY AND SLEEP MEDICINE. Clinical Tools to Assess Asthma Control in Children. Pediatrics. enero de 2017;139