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Tobacco smoke particles and indoor air quality (ToPIQ)
Germany (bvmd) - Goethe-Universitaet, Frankfurt
Goethe-University Frankfurt am Main, Institute of Occupational, Social and Environmental Medicine
Prof. Dr. Dr. David Groneberg
Prof. Dr. Dr. David Groneberg, Markus Braun, Dr. Nicole Zulauf
Type of Research Project
- Basic science
What is the background of the project?
Second-hand smoke (SHS)-associated particulate matter (PM) has to be seen as an independent health hazard and needs to be discussed separately from the already well-known toxic and carcinogenic compounds contained in cigarette smoke. Primarily, the ToPIQ studies conduct a field research with focus on PM concentration of different tobacco products and within various microenvironments. Especially, investigation that focuses on different tobacco products and their concentration of deeply into the airways depositing PM-fractions (PM10, PM2.5 and PM1) are important. The ToPIQ studies approach this issue by device supported generation of indoor SHS and simultaneously measurements of PM concentration by laser aerosol spectrometry.
What is the aim of the project?
Brand-specific amounts of PM are of public interest and should be investigated and compared.
What techniques and methods are used?
An automatic environmental tobacco smoke emitter placed in a glass-chamber generates SHS. Tobacco products are smoked automatically according to a standardized protocol. Mean concentrations (C mean) and the area under the curve (AUC) of PM released by different brands and the 3R4F standard research cigarette of the University of Kentucky, USA, are measured and compared with each other.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The students should bring at least 4 packages of commercial cigarette brands in their country (the cost will be reimbursed by the institute upon presentation of the invoice). After incorporation: - independent and active working in the smoking of the cigarette brands brought with them in our dedicated smokers' cabin -independent evaluation and interpretation of the measured results with possibly even compilation of the statistics
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Practical work in laboratory circumstances. Theorectical introduction and background information, but no planned teaching.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Independent and active working in the smoking of the cigarette brands brought with them in our dedicated smokers' cabin. If necessary, writing a scientific report.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Mueller D; Uibel S; Braun M; Klingelhoefer D; Takemura M; Groneberg DA: Tobacco smoke particles and indoor air quality (ToPIQ) - the protocol of a new study. J Occup Med Toxicol. 2011 Dec 21;6:35. doi: 10.1186/1745-6673-6-35.
- Gerber A; Hofen-Hohloch AV; Schulze J; Groneberg DA: Tobacco smoke particles and indoor air quality (ToPIQ-II) - a modified study protocol and first results. J Occup Med Toxicol. 2015 Feb 15;10:5. doi: 10.1186/s12995-015-0047-8.
- Braun M; Fromm EL; Gerber A; Klingelhöfer D; Müller R; Groneberg DA: Particulate matter emissions of four types of one cigarette brand with and without additives: a laser spectrometric particulate matter analysis of secondhand smoke. BMJ Open. 2019 Jan 15;9(1):e024400. doi: 10.1136/bmjopen-2018-024400.
- Braun M; Koger F; Klingelhöfer D; Müller R; Groneberg DA: Particulate Matter Emissions of Four Different Cigarette Types of One Popular Brand: Influence of Tobacco Strength and Additives. Int J Environ Res Public Health. 2019 Jan 17;16(2). pii: E263. doi: 10.3390/ijerph16020263.
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