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Multicentric Study of Cervical Cancer Screening and Triage with Human Papillomavirus Testing (ESTAMPA).
Bolivia (IFMSA-Bolivia) - Major, Real and Pontifical University “San Francisco de Xavier de Chuquisaca”, Sucre, Oropeza, Chuquisaca, Bolivia.
Centre of Social Interaction, Research and Development (CISID) - Faculty of Medicine(UMRPSFXCH)
Prof. Dr. Carolina Terán Calderón MD. MPH. PhD.
Prof. Dr. Carolina Terán Calderón MD. MPH. PhD.
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Chuquisaca has determined to become a benchmark in the south of Bolivia in the detection and early treatment of oncological pathology, in particular to contribute to the reduction of cervical cancer morbidity. To implement this initiative, the department has created Chuquisaqueño Institute of Oncology (ICO). In Bolivia, Cervical Cancer (CaCu) is the main cause of disease and death in women of childbearing age. It is the most frequent cancer site in women in the period 1977- 2012. The number of women with cervical cancer (2,029) is three times higher than those with breast cancer (807). According to the analysis carried out by the program in the country, around 2 to 3 women per day die. ESTAMPA is a multicentric study with participation of 12 countries in Latin America, led by the International Agency for Research on Cancer; Bolivia participates in the study through the Faculty of Medicine of the Major, Real and Pontifical University “Saint Francis of Xavier of Chuquisaca” (UMRPSFXCH).
What is the aim of the project?
To Investigate the performance of emerging screening and triage techniques for cervical cancer in women over 30 years of age and evaluate the feasibility of different approaches for implementation of organized screening programs based on Human Papillomavirus testing.
What techniques and methods are used?
This is a cross sectional screening study in which Human Papillomavirus testing will be carried out in a large sample of women 30-64 years of age in multiple centers (at least 50,000 women for primary screening, between 5,000 and 10,000 per site). All Women with Human Papillomavirus Positive (estimated at approximately 10% of screened women, detected by Human Papillomavirus tests) will be referred to Visual Inspection of the Cervix (VIA, Colposcopy), histological diagnosis and treatment as needed. At a second visit 18 months later all women who were selected for colposcopy after the initial test, will be tested again for Human Papillomavirus, and those testing positive will be referred for a final colposcopic evaluation, diagnosis and treatment as needed. Enrolment specimens from all women referred to colposcopy will be used to prepare a cervical cytology and will be tested with the different molecular methods under evaluation. Histological diagnosis of Squamous Intraepithelial Lesion Positive (HSIL+) at the first or second round of examinations will be the gold standard to evaluate the performance of the different triage tests to predict precancerous lesions among Human Papillomavirus Positive Women.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
● To participate in the workshops for interviewers ● To participate as interviewer during the recruitment of participants ● To participate as assistant in the clinic (during the cervical samples collection) ● To participate filling the database ● To participate as assistant in the Hospital (during the Visual Inspection of the Cervix and (VIA, Colposcopy) ● To participate organizing samples and aliquots in the lab (pathology lab and Human Papillomavirus lab)
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
- Seminars - Workshops - Lectures These will be provided during the first week of the exchange by the tutor. The topics will be: Colposcopy, Histological Diagnosis of Cervical Cancer and Treatment as appropriate.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
- Ability to teamwork - Ability to communicate with patients (women)
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Dr. Fulvio Antonio M. Arteaga Vera (1); Dra. Viviana P. Ortega Almendras (2); Dra. Fabiola Ponce Fuentes (3). CÁNCER DE CUELLO UTERINO. Aspectos a tomar en cuenta. Revistas Bolivianas [Internet]. 2011 [15/03/2019]; Volumen (15). Disponible en: http://www.revistasbolivianas.org.bo/scielo.php?pid=S0004-05252011000100002&script=sci_arttext
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