Vascular dysfunction in chronic inflammation
Serbia (IFMSA-Serbia) - University of Novi Sad, Novi Sad
Prof. Otto Barak, MD, PhD
Prof. Otto Barak, MD, PhD
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes No No No Yes Yes
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Vascular dysfunction and accelerated atherosclerosis related to chronic inflammation and immune activation may contribute to increased cardiovascular risk in this unique patient population. Previous studies have examined two distinct aspects of vascular dysfunction in chronic inflammation: endothelial microparticles (EMPs) and endothelium-dependent vascular relaxation, although the potential integration of EMP levels and endothelium-dependent vascular relaxation (flow mediated dilation, FMD) has yet to be examined. Recently, novel mechanisms have been revealed in the pathogenesis of cardiovascular disease that may play an important role in driving the increased cardiovascular risk associated with chronic inflammation and underlie the fore mentioned impaired FMD and elevated EMPs.
What is the aim of the project?
The central question of this study is whether changes in oscillatory shear pattern would further deteriorate the already impaired vascular function observed in chronic inflammation.
What techniques and methods are used?
Flow-mediated dilation (FMD) is an non-invasive vascular ultrasound technique that indirectly assesses the bioavailability of endothelial NO, a marker of endothelial function. The diameter of the target artery is measured by high-resolution external vascular ultrasound in response to an increase in blood flow (causing shear-stress). This, in return, causes endothelium-dependent dilation. Brachial artery diameter is measured during three conditions; baseline, during reactive hyperaemia and finally after the administration of sublingual nitroglycerin. Young adults with risk factors for atherosclerosis and cigarette smokers are the primary group analysed.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Selected students will be a part of the research team and be in charge for certain responsibilities depending on their abilities, previous experience and attitudes. They will be directly included in performance of high resolution ultrasound transducer needed for imaging targeted vessel and responsible for part of the experimental work, precisely Flow-mediated dilation (FMD) technique. The student is expected to communicate with the participants throughout the experiment, as well as perform data collection and analysis required from the mentor. He/she should gain a general grasp on concepts and skills that are required such as work with an ultrasound and the concept of endothelial-dependent dilation, understanding of the methods, operation of the instrumentation used and interpretation of the results. All tasks will be done under supervision.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The supervisor will prepare literature and organize courses to prepare students for the experiment.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Subjects passed: Physiology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Barak OF; Mladinov S; Hoiland RL; Tremblay JC; Thom SR; Yang M; Mijacika T; Dujic Z. Disturbed blood flow worsens endothelial dysfunction in moderate-severe chronic obstructive pulmonary disease. Sci Rep. 2017;7(1):16929. doi: 10.1038/s41598-017-17249-6