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The causes of early fetal loss under polycystic ovary syndrome conditions.
Sweden (IFMSA-Sweden) - Goteborgs Universitet, Gothenburg
Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg. Medicinaregatan 11 Box 430, 405 30 Göteborg.
Linus R. Shao
Type of Research Project
- Basic science
What is the background of the project?
Clinical miscarriage is the most common and distressing complication of pregnancy. Although epidemiological and clinical studies suggest that polycystic ovary syndrome (PCOS) may be attributed to, or associated with miscarriage which leads to human reproductive failure, the mechanisms behind miscarriage due to the impact of PCOS on uterine function remain unclear. Does insulin resistance itself and/or factors that promote uterine dysfunction have a pathogenic role in the onset of miscarriage? What are the main targets and effectors of insulin resistance in the uterus during implantation and pregnancy? How does the improvement in whole body (systemic) and organ-specific insulin sensitivity by pharmacological treatment correlate with the prevention of miscarriage in PCOS patients? Answering these questions will clarify whether insulin resistance actually contributes to miscarriage. Mitochondria as molecular platforms integrate multiple cellular signaling pathways, and we propose that defective regulation of these processes might be one of the underlying mechanisms of miscarriage observed in obese and PCOS patients.
What is the aim of the project?
We hypothesized that impaired uterine insulin sensitivity exerts a causative role in miscarriage. The aim of the project will therefore be to evaluate theory through regulating mitochondrial-mediated oxidative stress, inflammatory response, uterine epithelial- stromal cell interaction, and implantation-related marker expression.
What techniques and methods are used?
Histology and immunostainings, Western blot analysis, Quantitative real-time polymerase chain reaction (PCR), and enzyme-linked immunosorbent assay (ELISA) will be used in all stages of the project.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Morphological analysis of animal tissues. To investigate novel intervention strategies using different animal models, clinical samples and molecular approaches including but not limited to RNA sequencing, microarray, Quantitative Real-time polymerase chain reaction (PCR) Analysis, Mass Spectrometry, standard protein as well as immunohistochemical and immunofluorescence techniques to decipher pathways involved in insulin resistance and endometrial dysfunction.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Related background of our research will be provided (about 4 hours).
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Because this project will use very specific lab methods, basic knowledge in biology or those lab procedures are recommended.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Students in biomedical fields
- Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome. Zhang Y; Hu M; Meng F; Sun X; Xu H; Zhang J; Cui P; Morina N; Li X; Li W; Wu XK; Brännström M; Shao R; Billig H. EBioMedicine. 2017 Apr;18:157-170. doi: 10.1016/j.ebiom.2017.03.023. Epub 2017 Mar 18.
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