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Genetic testing for oncology and hereditary illnesses.
Spain (IFMSA Spain) - University of La Laguna, Santa Cruz de Tenerife
Unidad de diagnóstico molecular del Hospital Universitario de Canarias (Ofra S/N, CP: 38320)
Felícitas Días-Flores Estévez
Felícitas Días-Flores Estévez
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
In this unit, genetic studies are carried out daily, especially in oncology and hereditary diseases, so it is not a research project in itself, but a laboratory work related to genetics. Therefore, students will learn about different aspects of research in the day, will be able to perform different genetic analysis. Also, with the results of the genetic testing we study the role of the genome in drug response via pharmacogenomics and with the quantification of the viral load using NATs.
What is the aim of the project?
The aim of the unit is to analyze and perform genetic studies in oncological patients or with hereditary diseases.
What techniques and methods are used?
For the analysis of the DNA samples, these usually come prepared (in the hospital we have a laboratory exclusively dedicated to this). In the case of having to extract DNA we perform: purification of DNA from different samples and amplification of it by PCR techniques. With the DNA sample, those specific mutations are searched by: Real Time Polymerase Chain Reaction (PCR), Arrays and NGSequencing (depending on which is the background of the patient sample). IFMSA International Secretariat, c/o IMCC, Nørre Allé 14, 2200 København N., Denmark Subsequently, the results are compared with the genomic databases. The data will be analyzed statistically to reflect the correlation of the disease with the genetic base. In addition, in some cases, the data will be used to conduct small prevalence studies at the hospital level.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
As long as they perform basic lab work such as being able to use a pipette, they will not need more initial abilities. At first, the unit will be more watchful of the student’s management with the tools. This will last until the student adapts to the hospital. From then on, they will be on their own with the occasional assistance of the experts related to the project, who will be always ready for answering any question. The student will observe and perform every techniques used in the lab: Real Time Polymerase chain reaction (PCR), Arrays and NGSequencing. The student will also be involved in data analysis, IFMSA International Secretariat, c/o IMCC, Nørre Allé 14, 2200 København N., Denmark after learning to properly develop the basic laboratory work.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student will be integrated in the seminars and courses taught in the service.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student must learn the meaning of all the techniques and methods used in the unit, must be able to perform them, must know how to give and interpret the results and how to assist to genetic counseling committee and the genetic counseling consultation.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
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