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Metabolic consequences of sleep loss in adults
Sweden (IFMSA-Sweden) - Uppsala Universtitet, Uppsala
Departement of Neuroscience
Lieve van Egmond
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Sleep is important for a person’s psychological and physiological well-being. Sleep loss and low-quality of sleep are associated with several metabolic, cardiovascular, neurological and psychological disorders. Regarding metabolism, acute sleep loss or abnormal sleep habits have been linked to metabolic dysregulations - the most important of which are type 2 diabetes and obesity. Hormonal signals regulating important functions, such as energy expenditure, satiety, hunger and lipid metabolism, are modulated by the daily patterns of sleep and circadian rhythm. It is therefore evident that clinical studies aimed to deepen the knowledge the connection between sleep deprivation and metabolic disorders are essential.
What is the aim of the project?
Explore the psycho-metabolic consequences of one night of sleep loss in a healthy and metabolically vulnerable population.
What techniques and methods are used?
In this study, various tests are used: polysomnography (golden standard in sleep research), cognitive performance tests and drowsiness assessments. In the morning (student will not be involved in this part, except upon request), blood samples are taken, eye-tracking tests are performed, blood pressure is measured, and a cold pressor test is executed while measuring metabolic rate. For the polysomnography we will use sleep scoring to categorise the brain activity into the different sleep phases and this will be done by a sleep-scoring expert. The rest of the data from the conducted tests, will be entered into the database and analysed using SPSS (Statistical Package for Social Sciences, which is a statistical analysis tool).
What is the role of the student?
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The work is often conducted between the hours 19:30 and 07:00. Sometimes this includes sleeping at the lab (we have facilities for this) and sometimes staying awake during the night. If there are no/less participants, you will work during normal office hours. After our training, the student is expected to work independently with participants, be able to set up a polysomnographic analysis (putting electrodes, setting up the tests), conduct cognitive tests. The student will not take part of the data analysis due to the limited time to learn the techniques and interpret the data.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Self-study to understand the basics of sleep and sleep research if wanted by the student
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Motivated student, at least 3 years of education in the (bio)medical field. Need to be able to work independently, have a big interest in human research.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Metabolic consequences of sleep and sleep loss. Van Cauter; Spiegel K; Tasali E; Leproult R. Sleep Med. 2008 Sep;9 Suppl 1:S23-8. doi: 10.1016/S1389-9457(08)70013-3.
- Determinants of shortened; disrupted; and mistimed sleep and associated metabolic health consequences in healthy humans. Cedernaes J; Schiöth HB; Benedict C. Diabetes. 2015 Apr;64(4):1073-80. doi: 10.2337/db14-1475.
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